重金属对秀丽线虫毒性排序的Meta回归分析

doi:10.3969/j.issn.1004-616x.2013.03.010

癌变·畸变·突变

重金属对秀丽线虫毒性排序的Meta回归分析

王萌¹,余小金¹，* ,闵捷¹,刘冉²,唐萌²

( 1. 东南大学公共卫生学院流行病与卫生统计学系，江苏南京 210009；2. 东南大学公共卫生学院环境医学工程教育部重点实验室，江苏南京 210009 )

收稿日期:2013-01-10 修回日期:2013-04-07 出版日期:2013-05-30 发布日期:2013-05-30
通讯作者: 余小金， E-mail： xiaojinyu@seu.edu.cn
作者简介:王萌(1988- )，女，山东省日照市人，硕士，研究方向：生物统计方法在医学中的应用。E-mail：mengwang0521@ 163.com
基金资助:
国家自然科学基金项目(30972504，81172697)，国家重大科学研究计划项目(2011CB933404)

Meta regression analysis of heavy metal toxicity on Caenorhabditis elegans

WANG Meng1，YU Xiao-jin¹，*，MIN Jie¹，LIU Ran²，TANG Meng²

(1. Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210009; 2. Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China)

Received:2013-01-10 Revised:2013-04-07 Online:2013-05-30 Published:2013-05-30
Contact: YU Xiao-jin， E-mail： xiaojinyu@seu.edu.cn

摘要/Abstract

摘要：

目的：基于已发表的重金属对秀丽线虫毒性作用的文献，在排除其他影响因素的前提下，综合分析和比较重金属对秀丽线虫的毒性作用大小。方法：利用Scan It软件提取了20篇国内外相关文献中以图形表达的不同重金属对秀丽线虫不同指标的毒性数据，将相同指标进行汇总，以毒性指标终点为因变量，金属种类、浓度、暴露时间、发育期等为自变量，进行Meta回归模型分析。结果：各金属对秀丽线虫死亡率影响大小次序为：汞 (mercury，Hg)＞铜 (copper，Cu)＞铅 (lead，Pb)＞铬 (chromium，Cr)＞铝 (aluminum，Al)＞镉(cadmiun，Cd)＞钴(cobalt，Co)＞镍(nickel，Ni)＞锌(zinc，Zn)；对体长的影响大小次序为：Pb＞银 (silver，Ag) ＞Hg＞Co＞Al＞Cr＞Zn＞钙 (calcium，Ca)＞Ni；对世代时间的影响大小次序为：Ni＞Al＞Co＞Ag＞Cr＞Zn＞Cu＞Pb；对头部摆动频率的影响大小次序为：Hg＞Pb＞Ni＞Ag＞Cu＞Zn＞Cr＞Co＞Cd＞Al。结论：Meta回归模型可用于分析不同重金属的研究，并对重金属毒性进行有效排序，但有些浓度下的毒性仍需要结合实验进行综合分析和验证。

关键词: Meta回归, 重金属毒性排序, 秀丽线虫

Abstract:

OBJECTIVE: Based on the published literature of heavy metal toxicity on Caenorhabditis elegans，and after controlling the effects of other factors，we analyzed and compared the toxicity of heavy metals on Caenorhabditis elegans. METHODS：We used Scan It software to extract data from 20 related literature which contained figures expressing different indices of toxicity of various heavy metals on Caenorhabditis elegans，we then built a Meta regression model using toxicity indices as the dependent variables，and different metals，concentration，exposure time，etc. as independent variables. RESULTS：The order of heavy metal on the mortality of Caenorhabditis elegans was：Mercury (Hg)＞Copper (Cu)＞Lead (Pb)＞Chromium (Cr)＞Aluminum (Al)＞Cadmiun (Cd)＞Cobalt (Co)＞Nickel (Ni)＞Zinc (Zn)；affecting body size was：Pb＞Silver (Ag)＞Hg＞Co＞Al＞ Cr＞Zn＞Calcium (Ca)＞Ni；the effect on general time was：Ni＞Al＞Co＞Ag＞Cr＞ Zn＞Cu＞Pb； with head thrashes was：Hg＞Pb＞Ni＞Ag＞Cu＞Zn＞Cr＞ Co＞Cd＞Al. CONCLUSION：Meta regression model could be used to integrate information on the toxicity of different heavy metals，and to sort them in order. However，more experimental data on sorting of toxicity is necessary to validate the toxicity of some metals.

Key words: meta regression, toxicity sorting of heavy metal, Caenorhabditis elegans

王萌,余小金,闵捷,刘冉,唐萌. 重金属对秀丽线虫毒性排序的Meta回归分析[J]. 癌变·畸变·突变, doi: 10.3969/j.issn.1004-616x.2013.03.010.

WANG Meng，YU Xiao-jin，MIN Jie，LIU Ran，TANG Meng. Meta regression analysis of heavy metal toxicity on Caenorhabditis elegans[J]. Carcinogenesis, Teratogenesis & Mutagenesis, doi: 10.3969/j.issn.1004-616x.2013.03.010.

参考文献

[1] 张燕芬，王大勇. 利用模式动物秀丽线虫建立环境毒物毒性的评估研究体系[J]. 生态毒理学报，2008，3 (4)：313-322.

[2] 陈耀龙，于洁，张文娟，等. 循证医学术语介绍VII[J]. 中国循证医学杂志，2009，9 (12)：1272-1276.

[3] Chu KW，Chow KL. Synergistic toxicity of multiple heavy metals is revealed by a biological assay using a nematode and its transgenic derivative[J]. Aquat Toxicol，2002，61 (1/2)：53-64.

[4] Wang Y，Xie W，Wang DY. Transferable properties of multi-biological toxicity caused by cobalt exposure in Caenorhabditis elegans[J]. Environ Toxicol Chem， 2007，26 (11)：2405-2412.

[5] Xing X，Rui Q，Wang D. Lethality toxicities induced by metal exposure during development in nematode Caenorhabditis elegans[J].Bull Environ Contam Toxicol，2009，83 (4)：530-536.

[6] Wang DY，Yang P. Silver exposure causes transferable defects of phenotypes and behaviors in nematode Caenorhabditis elegans[J]. Environ Bioindicators，2007，2 (2)：1-10.

[7] 王大勇，胡亚欧，许雪梅. 铬暴露导致的秀丽线虫多重毒性的世代间比较[J]. 生态毒理学报，2007，2 (3)：297-303.

[8] Wang DY，Yang P. Multi-biological defects caused by lead exposure exhibit transferable properties from exposed parents to their progeny in Caenorhabditis elegans[J]. J Environ Sci， 2007，19 (110)：1367-1372.

[9] 汪洋，王大勇. 铜中毒引起的秀丽线虫世代间可传递的缺陷[J]. 安全与环境学报，2007，7 (2)：10-14.

[10] Wang DY，Wang Y. Nickel sulfate induces numerous defects in Caenorhabditis elegans that can also be transferred to progeny[J]. Environ Pollution，2008，151 (3)：585-592.

[11] Wang DY，Xing XJ. Assessment of locomotion behavioral defects induced by acute toxicity from heavy metal exposure in nematode Caenorhabditis elegans[J]. J Environ Sci，2008，20 (9)：1132-1137.

[12] Wang DY，Shen LL，Wang Y. The phenotypic and behavioral defects can be transferred from zinc-exposed nematodes to their progeny[J]. Environ Toxicol Pharmacol，2007，24 (3)：223-230.

[13] Wang DY，Xing XJ. Pretreatment with mild metal exposure suppresses the neurotoxicity on locomotion behavior induced by the subsequent severe metal exposure in Caenorhabditis elegans[J]. Environ Toxicol Pharmacol，2009，28 (30)：459-464.

[14] 王大勇，杨燚超，汪洋. 秀丽线虫中铝暴露导致的多重毒害在世代间具有可转移特性[J]. 中华预防医学杂志，2009，43 (1)：45-51.

[15] Xing XJ，Du M，Zhang YF，et al. Adverse effects of metal exposure on chemotaxis towards water-soluble attractants regulated mainly by ASE sensory neuron in nematode Caenorhabditis elegans[J]. J Environ Sci，2009，21 (12)： 1684– 1694.

[16] Wang HH，Robert L. Wick，Xing BS. Toxicity of nanoparticulate and bulk ZnO，Al2O3 and TiO2 to the nematode Caenorhabditis elegans[J]. Environ Pollution，2009， 157 (4)：1171-1177.

[17] Wang DY，Liu PD，Yang YC，et al. Formation of a combined Ca/Cd toxicity on lifespan of nematode Caenorhabditis elegans[J]. Ecotoxicol Environ Saf，2010，73 (6)：1221-1230.

[18] Zhang YF，Ye BP，Wang DY. Effects of metal exposure on associative learning behavior in nematode Caenorhabditis elegans[J]. Arch Environ Contam Toxicol，2010，59 (1)：129-136.

[19] Ye BP，Rui Q，Wu QL，et al. Metallothioneins are required for formation of cross-adaptation response to neurobehavioral toxicity from lead and mercury exposure in nematodes[J]. PLoS One，2010，5 (11)：1-12.

[20] Wu QL，Yang P，Wang DY. Mercury exposure can cause transferable defects of phenotypes and behaviors in nematode Caenorhabditis elegans progeny[J]. J Southeast Univ：Med Sci Edi，2010，29 (1)：1-9.

[21] Yang YC，Xing XJ，Wang DY. The close association of pharyngeal pumping with mean lifespan can be observed in metal exposed nematode Caenorhabditis elegans[J]. J Southeast Univ：Med Sci Edi，2010，29 (1)：10-16.

[22] Wu QL，He KW，Liu PD，et al. Association of oxidative stress with the formation of reproductive toxicity from mercury exposure on hermaphrodite nematode Caenorhabditis elegans[J]. Environ Toxicol Pharmacol，2011，32 (2)：175-184.

[23] Lau J，Ioannidis JP，Schmid CH. Summing up evidence：one answer is not always enough[J]. Lancet，1998，351 (9096)： 123-127.

重金属对秀丽线虫毒性排序的Meta回归分析

Meta regression analysis of heavy metal toxicity on Caenorhabditis elegans

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 0

编辑推荐

Metrics

本文评价