XPD基因751位点单核苷酸多态与肺癌遗传易感性关联的Meta分析

doi:10.3969/j.issn.1004-616x.2016.04.009

摘要/Abstract

摘要： 目的：人类着色性干皮病基因D（XPD）是核苷酸切除修复途径中的关键基因之一，其单核苷酸多态（SNP）与肺癌的遗传易感性相关联，但研究结论不一，本研究拟采用Meta分析的方法对2000 —2014年间发表的相关文献进行综合，评价XPD基因751位点SNP与肺癌遗传易感性的关联。方法：检索PubMed、CNKI（中国知网）、cqVIP（维普资讯网）、万方全文数据库中关于XPD基因Lys751Gln位点多态与肺癌遗传易感性关联的病例对照研究。按照拟定标准筛查并纳入符合标准的文献，采用RevMan 4.2软件对入选文献进行异质性检验，计算合并相对危险度（OR值）及其95%可信区间（95%CI），同时绘制漏斗图，估计发表偏倚的影响。结果：共纳入28篇国内外文献，累计病例9012例，对照10542例，杂合基因型Lys/Gln与野生基因型Lys/Lys相比较，采用随机效应模型计算合并OR值为1.18，95%CI（1.07，1.31），P=0.001；突变基因型Gln/Gln与野生基因型Lys/Lys相比较，采用固定效应模型分析计算合并OR值为1.28，95%CI（1.14，1.44），P<0.01。亚组分析结果显示高加索人群中，XPD基因751位点多态与肺癌遗传易感性相关联。结论：XPD基因751位点Gln/Lys和Gln/Gln基因型的个体，其肺癌发病风险显著增加。

关键词: 人类着色性干皮病基因D, 单核苷酸多态性, 肺癌, Lys751Gln, Meta分析

Abstract: OBJECTIVE: Reports on association between the xeroderma pigmentosum group D (XPD) and genetic susceptibility to lung cancer have not been consistent. Therefore, we have conducted a Meta analysis to review the association. METHODS: The databases of PubMed, CNKI, cqVIP or wanfang were retrieved to search for publications about case-control studies which were published from 2000-2014. The focus was on XPD 751 polymorphisms and genetic susceptibility to lung cancer. Relevant data were extracted from the selected publications. Corresponding combination methods were used and the pooled relative risk (OR) and its 95% confidence interval (95%CI) were calculated after the heterogeneity test with the statistical analysis software RevMan 4.2. Meanwhile, Funnel Plots were protracted to estimate the effect of publication bias. RESULTS: The study included 28 domestic and international reports with 9 012 cumulative subjects of case group and 10 542 controls. For the Lys/Gln versus the Lys/Lys variant groups, the OR was 1.18, the 95%CI was 1.07-1.31, and P=0.001 which reflected on random effect model. For the Gln/Gln versus the Lys/Lys variant groups, the OR was 1.28, the 95%CI was 1.14-1.44, and P=0.01, which reflected on fixed effect model. Subgroup analyses revealed that XPD 751 polymorphism was associated with genetic susceptibility to lung cancer. CONCLUSION: For individuals carrying the codon 751 Gln/Lys or Gln/Gln genotypes, the risk of lung cancer increased significantly.

Key words: xeroderma pigmentosum group D, single nucleotide polymorphisms, lung cancer, Lys751Gln, Meta-analysis

中图分类号:

R73-31

肖莎, 赵秀娟, 邝仕成, 刘云儒, 龙文芳, 杨建军, 黄海溶. XPD基因751位点单核苷酸多态与肺癌遗传易感性关联的Meta分析[J]. 癌变·畸变·突变, 2016, 28(4): 292-297.

XIAO Sha, ZHAO Xiujuan, KUANG Shicheng, LIU Yunru, LONG Wenfang, YANG Jianjun, HUANG Hairong. A Meta-analysis of the relationship between XPD 751 gene polymorphism and lung cancer[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(4): 292-297.

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