细胞周期蛋白E1与恶性肿瘤关系的研究进展

doi:10.3969/j.issn.1004-616x.2016.06.016

摘要/Abstract

摘要： 细胞周期蛋白E1（Cyclin E1），是由CCNE1基因编码的一种核蛋白，在细胞周期中表现为循环式的表达，在整个细胞周期进程中发挥至关重要的作用。该蛋白通过激活细胞周期蛋白依赖性激酶2（CDK2）并与之形成复合物，促进细胞通过细胞周期G1/S期限制点，发挥调控真核细胞有丝分裂的作用。正常情况下，Cyclin E1在细胞周期中有序的进行表达和降解。但在异常情况下，Cyclin E1在细胞周期中无序的不稳定表达可导致细胞周期失调控，干扰细胞的有丝分裂，进一步导致细胞染色体的不稳定性，促进肿瘤的发生。近期有研究表明Cyclin E1异常表达参与肿瘤治疗过程中肿瘤细胞对化疗药物产生的抵抗，并与喉癌、胃癌和肝癌等多种肿瘤的发生和发展相关。本文就细胞周期蛋白与恶性肿瘤的关系概况作一综述。

关键词: 细胞周期蛋白E1, 肿瘤化疗, 耐药, 细胞周期调控

中图分类号:

R730.2

游路宽, 佘亚军, 陈初鹏. 细胞周期蛋白E1与恶性肿瘤关系的研究进展[J]. 癌变·畸变·突变, 2016, 28(6): 487-490.

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