NGF和BDNF在肿瘤嗜神经侵袭中的异同性比较

doi:10.3969/j.issn.1004-616x.2016.06.017

癌变·畸变·突变 ›› 2016, Vol. 28 ›› Issue (6): 491-493.doi: 10.3969/j.issn.1004-616x.2016.06.017

NGF和BDNF在肿瘤嗜神经侵袭中的异同性比较

胡志豪, 李梦萦, 丁蕾蕾, 周琦, 宫亚欧, 杨胜利, 莫赛军

郑州大学基础医学院肿瘤教研室, 河南郑州 450001

收稿日期:2016-08-28 修回日期:2016-10-12 出版日期:2016-11-30 发布日期:2016-11-30
通讯作者: 莫赛军,E-mail:sjmo@zzu.edu.cn E-mail:sjmo@zzu.edu.cn
作者简介:胡志豪,E-mail:1939213738@qq.com。
基金资助:
国家自然科学青年基金（81101686）；河南省教育厅重点项目（12A310008，15A310029）；郑州大学医学院青年教师基金（JCYXY2016-YQ-02）；郑州大学创新创业训练计划项目（2016xjxm337）

Received:2016-08-28 Revised:2016-10-12 Online:2016-11-30 Published:2016-11-30

摘要/Abstract

摘要： 肿瘤嗜神经侵袭（PNI）是恶性肿瘤转移的一种特殊方式，往往导致手术切除瘤体不彻底和肿瘤复发。PNI发生的机制非常复杂，主要受到多种神经因子的调控，其中包括神经生长因子（NGF）和脑源性神经营养因子（BDNF）。本文就NGF和BDNF的研究进展和二者存在的异同点作一综述，并分析二者的竞争与协同关系，以期为PNI研究提供参考。

关键词: 嗜神经侵袭, 脑源性神经营养因子, 神经生长因子, 竞争, 协同

中图分类号:

R73-37

胡志豪, 李梦萦, 丁蕾蕾, 周琦, 宫亚欧, 杨胜利, 莫赛军. NGF和BDNF在肿瘤嗜神经侵袭中的异同性比较[J]. 癌变·畸变·突变, 2016, 28(6): 491-493.

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NGF和BDNF在肿瘤嗜神经侵袭中的异同性比较

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