绝经状态影响饮茶与乳腺癌患病风险关系的meta分析

doi:10.3969/j.issn.1004-616x.2018.05.013

癌变·畸变·突变 ›› 2018, Vol. 30 ›› Issue (5): 395-399.doi: 10.3969/j.issn.1004-616x.2018.05.013

绝经状态影响饮茶与乳腺癌患病风险关系的meta分析

肖红梅^1,2, 潘天齐¹, 董淑楠¹, 付凌萌¹, 王少康¹, 孙桂菊¹

1. 东南大学公共卫生学院营养与食品卫生学系, 环境医学工程教育部重点实验室, 江苏南京 210009;
2. 粤北人民医院, 广东韶关 512000

收稿日期:2017-10-09 修回日期:2018-06-08 出版日期:2018-09-30 发布日期:2018-09-30
通讯作者: 王少康,E-mail:shaokangwang@seu.edu.cn E-mail:shaokangwang@seu.edu.cn
作者简介:肖红梅,E-mail:Cathyzh518@163.com。
基金资助:
国家自然科学基金项目（81372985，81673147）

Menopausal status on risk for breast cancer from tea consumption: a meta-analysis

XIAO Hongmei^1,2, PAN Tianqi¹, DONG Shunan¹, FU Lingmeng¹, WANG Shaokang¹, SUN Guiju¹

1. Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, Jiangsu;
2. Yuebei People's Hospital, Shaoguan 512000, Guangdong, China

Received:2017-10-09 Revised:2018-06-08 Online:2018-09-30 Published:2018-09-30

摘要/Abstract

摘要： 目的：探讨绝经状态是否影响饮茶与乳腺癌患病风险之间的潜在关系。方法：以茶、茶多酚和乳腺癌为主题词联合检索Web of Science、PubMed、Medline、中国知网、维普、万方数据库1996年1月1日至2017年8月31日发表的相关文献。使用Stata 11.0软件进行效应值的合并和异质性检验，用NOS（New Castle Ottawa Scale）量表对每篇研究进行评分，通过Begg秩相关检验，Egger线性回归及剪补法计算发表偏倚。结果：本次研究共纳入9篇文献，通过比较茶饮品最高摄入量组和最低摄入量组乳腺癌的患病风险，结果初步表明饮茶对乳腺癌患病风险的影响无统计学意义（OR=1.01，95% CI：0.86~1.18），且绝经前（OR=0.92，95% CI：0.82~1.04）和绝经后（OR=1.11，95% CI：0.93~1.33）饮茶与乳腺癌患病的关联也无统计学意义（P < 0.05）。另外，在亚组分析中也未发现绝经状态会影响饮茶人群的乳腺癌患病风险。结论：饮茶与乳腺癌患病风险无关，且绝经状态不会影响饮茶人群的乳腺癌患病风险。但目前研究证据还比较有限。故在今后的研究中需开展大样本、多中心的队列或病例对照研究来进一步验证这一结论的准确性。

关键词: 茶, 乳腺癌, 绝经期, meta分析

Abstract: OBJECTIVE:To ascertain the potential relationship between tea consumption and risk of premenopausal and post-menopausal breast cancer. METHODS:Web of Science,PubMed,Medline,CNKI,VIP and WanFang database were independently searched from January 1st, 1996 to August 31st, 2017 by using "tea OR catechin OR tea polyphenol" AND "breast OR mammary" AND "cancer OR tumor OR carcinoma" as key words. The combination of the effect values and the heterogeneity test were performed using Stata 11.0 software. Each study was scored using the NOS (New Castle Ottawa Scale),and the publication bias was calculated using the funnel and Egger regression. RESULTS:A total of 9 studies (5 case-control studies;4 cohort studies) were included. The studies showed that tea intake was insignificantly associated with risk of breast cancer (OR=1.01,95% CI:0.86-1.18),the highest tea intake was also insignificant for risk of premenopausal (OR=0.92,95% CI:0.82-1.04) and postmenopausal breast cancers (OR=1.11,95% CI:0.93-1.33). In addition, we did not identify any statistically significant association between tea consumption and breast cancer risk in all the subgroup analyses (P < 0.05). CONCLUSION:In conclusion,our findings indicate that menopausal status had no effect on tea consumption and breast cancer risk. But the current evidence is still relatively limited. Therefore, large sample,multi-center cohort or case-control studies should be conducted to further clarify the accuracy of this conclusion.

Key words: tea, breast cancer, menopause, meta-analysis

中图分类号:

R151.3

肖红梅, 潘天齐, 董淑楠, 付凌萌, 王少康, 孙桂菊. 绝经状态影响饮茶与乳腺癌患病风险关系的meta分析[J]. 癌变·畸变·突变, 2018, 30(5): 395-399.

XIAO Hongmei, PAN Tianqi, DONG Shunan, FU Lingmeng, WANG Shaokang, SUN Guiju. Menopausal status on risk for breast cancer from tea consumption: a meta-analysis[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(5): 395-399.

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绝经状态影响饮茶与乳腺癌患病风险关系的meta分析

Menopausal status on risk for breast cancer from tea consumption: a meta-analysis

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