关键词: 食管鳞癌, 中性粒细胞/淋巴细胞比值, 血小板/淋巴细胞比值, 临床病理因素

Abstract: OBJECTIVE： To investigate relationships among neutrophil-lymphocyte ratio (NLR)，plateletlymphocyte ratio (PLR)， clinicopathological characteristics and prognosis of esophageal squamous cell carcinoma. METHODS： Retrospective analyses were conducted on 134 patients who had surgery for esophageal squamous cell carcinoma from January 1， 2010 to December 31， 2013. Relationships among NLR， PLR， clinicopathological characteristics and prognosis of these carcinomas were evaluated. RESULTS： The T stage of patients in the low NLR (<2.34) group was significantly earlier than those in the high NLR (≥ 2.34) group (P=0.001). The T stage of patients in the low PLR (<152.76) group was also significantly earlier than those in the high PLR (≥152.76) group (P < 0.01). The lesion length of patients in the low NLR (<2.12) group was significantly shorter than that in the high NLR (≥2.12) group (P < 0.01). Patients with low PLR (< 103.91) were also significantly shorter than those with high PLR (≥103.91) (P < 0.01). The 1，3，and 5 year survival rates and local control rates of the entire group were 88.1%，45.8%，33.9%，and 88.0%，69.0%， 67.4%，respectively. The 1，3，and 5 years of the transfer rates were 27.6%，54.9%，55.9%. The 1-，3-， and 5-year remote turnout rates of patients in the high NLR group were much higher than those in the low NLR group (P=0.012). The 1-，3-，and 5-year long-term turnout rates of patients in the high PLR group were much higher than those in the low PLR group (P=0.014). Multivariate analyses of survival show that only the N stage was an independent factor affecting the survival of patients (P=0.014). CONCLUSION： NLR and PLR are closely related to the clinicopathological characteristics and prognosis of patients. Patients with high NLR and high PLR had late T stage，longer lesion length and are more prone to distant metastasis.

Key words: esophageal squamous cell carcinoma, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, clinicopathological factors