光激活纳米材料用于肿瘤免疫治疗的研究进展

doi:10.3969/j.issn.1004-616x.2022.06.013

癌变·畸变·突变 ›› 2022, Vol. 34 ›› Issue (6): 471-475.doi: 10.3969/j.issn.1004-616x.2022.06.013

• 综述 • 上一篇

光激活纳米材料用于肿瘤免疫治疗的研究进展

许伟喆^1,2, 王芳^1,2, 褚洪迁^1,2

1. 北京市结核病胸部肿瘤研究所耐药结核病研究北京市重点实验室, 北京 101149;
2. 首都医科大学附属北京胸科医院转化医学研究室, 北京 101149

收稿日期:2022-07-20 修回日期:2022-10-09 发布日期:2022-12-03
通讯作者: 褚洪迁
作者简介:许伟喆，E-mail：zh7626252@163.com。
基金资助:
国家自然科学基金(82001946);北京市自然科学基金(7214300);北京市医院管理中心培育项目(PX2021061)

Received:2022-07-20 Revised:2022-10-09 Published:2022-12-03

摘要/Abstract

摘要： 癌症是危害人类健康的重大疾病，但传统的癌症治疗方法存在一定局限性。近年来，依靠激活人体免疫系统发挥抗肿瘤作用的免疫疗法逐渐兴起。但是，肿瘤免疫治疗的手段依然存在许多缺陷，常引起脱靶效应、变态反应、细胞因子风暴等免疫相关不良反应。为了克服这些缺点，实现对免疫治疗的有效控制，由光激活的纳米材料即通过光控来实现抗肿瘤免疫的手段引起了广泛关注。光控纳米材料能够实现在肿瘤部位选择性的激活抗肿瘤免疫作用，因此可有效降低免疫治疗的系统毒性。本文总结了目前常见的光激活纳米材料，包括上转换纳米颗粒(UCNPs)、金纳米颗粒(AuBPs)、碳纳米管、介孔二氧化硅纳米颗粒(MSN)和金属有机框架(MOFs)等，并论述了它们在抗肿瘤免疫治疗中的设计思路及研究现状。

关键词: 纳米材料, 光激活, 抗肿瘤免疫, 联合治疗

中图分类号:

R73-36

许伟喆, 王芳, 褚洪迁. 光激活纳米材料用于肿瘤免疫治疗的研究进展[J]. 癌变·畸变·突变, 2022, 34(6): 471-475.

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光激活纳米材料用于肿瘤免疫治疗的研究进展

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