长链非编码RNA BANCR在甲状腺癌中表达和作用的研究进展

doi:10.3969/j.issn.1004-616x.2023.03.015

摘要/Abstract

摘要： 随着甲状腺癌发病率的上升、分子生物学的发展以及分子检测技术水平的提高，长链非编码RNA(lncRNA)与甲状腺癌的关系逐渐被人们发现和重视。近年来lncRNA成为癌症发展机制及分子靶向治疗的研究热点，其中由BRAF基因激活的lncRNA BANCR被认为是甲状腺癌发生发展的重要影响因素之一。本文综合了国内外最新研究进展，总结了lncRNA BANCR在甲状腺癌中的表达情况及与肿瘤发生发展相关的机制，指出lncRNA BANCR对于甲状腺癌诊断和预后判断有重要影响，也可能是治疗甲状腺癌一个新的潜在靶点，其相关机制还需要进一步深入研究。

关键词: 长链非编码RNA, lncRNA BANCR, 甲状腺癌, 表达, 作用机制

中图分类号:

R736.1

任红臻, 张洁, 郭艳英. 长链非编码RNA BANCR在甲状腺癌中表达和作用的研究进展[J]. 癌变·畸变·突变, 2023, 35(3): 236-239.

参考文献

[1] SEIB C D, SOSA J A. Evolving understanding of the epidemiology of thyroid cancer[J]. Endocrinol Metab Clin N Am, 2019, 48(1):23-35.
[2] XING M Z, ALZAHRANI A S, CARSON K A, et al. Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer[J]. JAMA, 2013, 309(14):1493-1501.
[3] WANG J Y, YU F F, SHANG Y N, et al. Thyroid cancer:incidence and mortality trends in China, 2005-2015[J]. Endocrine, 2020, 68(1):163-173.
[4] PRETE A, BORGES DE SOUZA P, CENSI S, et al. Update on fundamental mechanisms of thyroid cancer[J]. Front Endocrinol, 2020, 11:102.
[5] 秦汝佳, 赵再礼, 孙传政. 长链非编码RNA在甲状腺癌中的研究进展[J]. 国际耳鼻咽喉头颈外科杂志, 2020, 44(1):33-36.
[6] JIANG M C, NI J J, CUI W Y, et al. Emerging roles of lncRNA in cancer and therapeutic opportunities[J]. Am J Cancer Res, 2019, 9(7):1354-1366.
[7] FLOCKHART R J, WEBSTER D E, QU K, et al. BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration[J]. Genome Res, 2012, 22(6):1006-1014.
[8] ZHANG G Y, CAI J R. Evaluation of prognostic value of lncRNA BANCR in tumor patients:a systematic review and meta-analysis[J]. J BUON, 2019, 24(6):2553-2559.
[9] XING M Z. Molecular pathogenesis and mechanisms of thyroid cancer[J]. Nat Rev Cancer, 2013, 13(3):184-199.
[10] 郝少龙, 马纪红, 韩威. BANCR在甲状腺乳头状癌中的研究进展[J]. 中华普外科手术学杂志:电子版, 2021, 15(2):232-234.
[11] LI X H, HE S K, MA B Y. Autophagy and autophagy-related proteins in cancer[J]. Mol Cancer, 2020, 19(1):1-16.
[12] 崔丹蕊, 刘波, 刘伟. 细胞自噬与肿瘤发生关系的研究进展[J]. 中国科学:生命科学, 2015, 45(6):593-603.
[13] WANG Y, GUO Q H, ZHAO Y, et al. BRAF-activated long non-coding RNA contributes to cell proliferation and activates autophagy in papillary thyroid carcinoma[J]. Oncol Lett, 2014, 8(5):1947-1952.
[14] 刘涛, 赵艳红, 王利萍, 等. 丝氨酸/苏氨酸蛋白激酶激活的长链非编码RNA对甲状腺癌细胞凋亡和自噬行为的影响[J]. 中南大学学报:医学版, 2018, 43(7):747-753.
[15] ZHENG H T, WANG M, JIANG L X, et al. BRAF-activated long noncoding RNA modulates papillary thyroid carcinoma cell proliferation through regulating thyroid stimulating hormone receptor[J]. Cancer Res Treat, 2016, 48(2):698-707.
[16] QU M Y, WAN S Y, REN B X, et al. Association between TSHR gene methylation and papillary thyroid cancer:a meta-analysis[J]. Endocrine, 2020, 69(3):508-515.
[17] 唐博瑞, 宋檀婧, 孙立栋. EZH2与癌症[J]. 华中科技大学学报:医学版, 2022, 51(3):415-419.
[18] ZHENG H T, XU J, HAO S L, et al. Expression of BANCR promotes papillary thyroid cancer by targeting thyroid stimulating hormone receptor[J]. Oncol Lett, 2018, 16(2):2009-2015.
[19] 郝少龙, 刘新承, 马纪红, 等. BANCR对甲状腺乳头状癌TSHR表达调控的研究进展[J]. 中华普外科手术学杂志:电子版, 2016, 10(4):358-360.
[20] 任乃昕, 戚基萍. 甲状腺乳头状癌的分子生物学研究[J]. 临床与病理杂志, 2021, 41(10):2421-2427.
[21] NIKIFOROV Y E, NIKIFOROVA M N. Molecular genetics and diagnosis of thyroid cancer[J]. Nat Rev Endocrinol, 2011, 7(10):569-580.
[22] WANG Y Y, LIN X D, FU X H, et al. Long non-coding RNA BANCR regulates cancer stem cell markers in papillary thyroid cancer via the RAF/MEK/ERK signaling pathway[J]. Oncol Rep, 2018, 40(2):859-866.
[23] PRZYBYLA L, MUNCIE J M, WEAVER V M. Mechanical control of epithelial-to-mesenchymal transitions in development and cancer[J]. Annu Rev Cell Dev Biol, 2016, 32:527-554.
[24] WANG Y Y, GU J J, LIN X D, et al. lncRNA BANCR promotes EMT in PTC via the Raf/MEK/ERK signaling pathway[J]. Oncol Lett, 2018, 15(4):5865-5870.
[25] LIAO T, QU N, SHI R L, et al. BRAF-activated LncRNA functions as a tumor suppressor in papillary thyroid cancer[J]. Oncotarget, 2017, 8(1):238-247.
[26] ZHANG J J, DU Y Y, ZHANG X X, et al. Downregulation of BANCR promotes aggressiveness in papillary thyroid cancer via the MAPK and PI3K pathways[J]. J Cancer, 2018, 9(7):1318-1328.
[27] LIU X F, HAO J L, XIE T, et al. The BRAF activated non-coding RNA:a pivotal long non-coding RNA in human malignancies[J]. Cell Prolif, 2018, 51(4):e12449.
[28] SHI C L, CAO J, SHI T F, et al. BRAF V600E mutation, BRAF-activated long non-coding RNA and miR-9 expression in papillary thyroid carcinoma, and their association with clinicopathological features[J]. World J Surg Oncol, 2020, 18(1):145.
[29] STOJANOVIĆ S, ŠELEMETJEV S, ĐORIĆ I, et al. Elevated BANCR expression levels have different effects on papillary thyroid carcinoma progression depending on the presence of the BRAFV600E mutation[J]. Eur J Surg Oncol, 2020, 46(10 Sup A):1835-1842.
[30] HUSSEN B M, AZIMI T, ABAK A, et al. Role of lncRNA BANCR in human cancers:an updated review[J]. Front Cell Dev Biol, 2021, 9:689992.