镉诱导细胞焦亡相关机制的研究进展

doi:10.3969/j.issn.1004-616x.2023.06.014

摘要/Abstract

摘要： 镉是环境中普遍存在的微量元素，也是常见的环境污染物之一，随着食物链进入体内，通过长期蓄积而危害人类健康。体内过量累积的镉会引起细胞死亡、组织损伤，内分泌紊乱和生殖功能障碍等，诱发糖尿病、心血管疾病和肿瘤等多种疾病。细胞焦亡是新发现的一种细胞程序性死亡方式，依赖炎性半胱天冬酶，在细胞膜上形成孔隙，细胞膜破裂，内容物流出，并伴有大量炎症因子释放，从而募集更多的炎性细胞，扩大炎症反应。细胞焦亡在炎症、脓毒症、肿瘤等疾病发生过程中，发挥重要作用。因此，本文对细胞焦亡的形成及镉诱导细胞焦亡相关机制进行综述，拟为防护镉导致的疾病提供新的思路。

关键词: 镉, 细胞焦亡, 炎症小体复合物, 氧化应激

中图分类号:

R994.6

廖明星, 李仁燕. 镉诱导细胞焦亡相关机制的研究进展[J]. 癌变·畸变·突变, 2023, 35(6): 482-484,488.

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