Carcinogenesis, Teratogenesis & Mutagenesis ›› 2001, Vol. 13 ›› Issue (1): 10-012.doi: 10.3969/j.issn.1004-616x.2001.01.004

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GENETIC POLYMORPHISM OF GLUTATHIONE S- TRANSFERASE T1 AND M1 IN SHANGHAI“INDIGENE”POPULATION

LIN Guo - fang1, MA Qing - wen1, ZHA Yong - lin2, LOU Ke - jian2, CHEN Ji - gang3, SHEN Jian - hua1   

  1. 1. Sino - German Laboratory of Toxicology ( DCLT), Shanghai Institute of Entomology, Chinese Academy of Sciences, Shanghai 200025, China; 2. County Mental Health Center, Qingpu, Shanghai 201700, China; 3. Municipal Center for Disease Control and Prevention, Shanghai 200336, China
  • Received:2000-04-05 Revised:2000-05-24 Online:2001-01-30 Published:2001-01-30

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Abstract: Purpose and Methods : Population polymorphisms of the GSTT1 and M1 genes in the Shanghai“indigene”group were evaluated using the PCR procedure. Results : In this group , the f requencies of GSTT1 null and GSTM1 null genotype are 48. 53 % and 54. 40 % , respectively. No significant differences were detected between urban individuals (49. 32 % and 48. 86 % , respectively) and an“indigene”group in suburb of Shanghai for GSTT1 and GSTM1 genotypes alone , as well as for four combined genotypes of GSTT1 and GSTM1. Conclusion : Between the“indigene”population in remote suburb and the urban population in downtown of Shanghai the genetic polymorphism dist ribution of GSTT1 and GSTM1 genes is proved to be homogenous.

Key words: GSTT1 and GSTM1 genes, genotype polymorphism, “indigene”Shanghai population

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