Carcinogenesis, Teratogenesis & Mutagenesis ›› 2001, Vol. 13 ›› Issue (1): 26-028.doi: 10.3969/j.issn.1004-616x.2001.01.009

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HUMAN PAPILLOMAVIRUS TYPES 16 AND 18 INVOLVEMENT IN A VERRUCOUS CARCINOMA OF THE VULVA

LI Cong - zhu1, CHEN Hai - bing2, LI Wei - qiu3, HUANG Ping1, YANG Zhan1   

  1. 1. Department of Gynecoloical Oncology, Shantou University Medical College Tumor Hospital, Shantoun 515031, China; 2. Department of Histology, Shantou University Medical College Shantou 515031; 3. Center Laboratory, Shantou University Medical College, Shantou 515031, China
  • Received:2000-05-19 Revised:2000-07-05 Online:2001-01-30 Published:2001-01-30

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Abstract: Purpose : To study the possible pathogenetic role of HPV16 E6 , E7 protein expression in verrucous carcinoma of the vulva. Methods : Immunohistochemist ry SABC method was used to examine HPV16/ 18E6 and HPV16E7 protein expression in the surgical specimens. Results : ①The most typical is koilocytosis , with perinuclear hole formation with a thick cytoplasmic border in the upper epithelial ; ②Immunohistochemical detection of E6 and E7 showed st rong positive psoduct s in the basal lamina of epidermis of cancer tissues ; ③There are only scattered positive cells for HPV E6 and weak positive or scattered st rong positive cells for HPV E7 in cancer nests ; ④HPV E6 and E7 in the adjacent tissue showed st rong positive expression whereas some region showed medium positive reaction. Conclusion : It is suggested that HPV16 E6 and E7 may be involved in the carcinogenesis of verrucous carcinoma.

Key words: vulva verrucous, human papillomavirus (HPV), immunohistochemist ry

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