Abstract: BACKGROUND & AIM: To probe the mechanism of potential carcinogenal effect on lung lesion in sprangue dawley (Sd) rats inhaled Cooking Siritch Oil Fume. MATERAIL AND METHODS: The pathomorphological variants of lung tissue were observed by microscope, Expression of P53 and P16 protein of Lung Tissues were observed by SABC method. Test animal were randomly divided into 3 test groups, such as exposure group dynamically inhaling (44.44±18.68) mg/m3 CSOF ,positive group pouring BaP and negative control group inhaling fresh air. All of the determinations and observations were done at the day 20th, 40th, 60th during the experiment. RESULTS: The main pathological changes of lung tissues in exposure group were inflammation, adenic metaplasia were also found. The expression of P53 protein was positive in exposure group, the expression of P16 protein decline. CONCLUSION: The cooking siritch oil fumes can induce the lung tissue damage.

Key words: Cooking Siritch Oil Fume (CSOF), Pathological changes, P53 protein, P16protein