Carcinogenesis, Teratogenesis & Mutagenesis ›› 2006, Vol. 18 ›› Issue (1): 58-060.doi: 10.3969/j.issn.1004-616x.2006.01.017

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Correlation Study on the Chemosensitivity in vitro by Peripheral Blood Lymphocyte and Tumor Cells of Patients with Esophageal Carcinoma

AI Jun;LIANG Suo-yuan;SHAN Bao-an;HE Lan-xin;REN Jing-rong   

  1. Hebei Cancer Institute The Four Hospital of Hebei of Medical University ,Shijiazhuang 050011, Hebei,China
  • Received:2005-01-11 Revised:2005-05-30 Online:2006-01-30 Published:2006-01-30
  • Contact: AI Jun

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Abstract: BACKGROUND & AIM: To study the correlation of chemosensitivity no peripheral blood lymphocyte and tumor cells . MATERIAL AND METHODS: 3-( 4，5-dimethylthiazol-2-yl )-2, 5- diphenyltetrazolium bromide (MTT) method was used to test the sensitivity of the peripheral blood lymphocyte and the tumor cells of 32 patients with esophageal carcinoma to 9 kinds of anti-cancer drugs. RESULTS: The peripheral blood lymphocyte and the tumor cells were sensitive to chemotherapeutic drugs of 5-fluorouracilum (5-Fu),diamminedichloroplatinum（DDP），carboplatinum (CBP)，methotrexate (MTX) and cyclophosphamide（CTX），but not sensitive to adriamycin ( ADM) ,vincristin (VCR); There was alack of correlation by lymphocyte and tumor cells to Vp-16 , THP. CONCLUSION:There were no statistical differences in the rate of sensitivity to the above-mentioned drugs between the peripheral blood lymphocyte and the tumor cells (P>0.05).Peripheral blood lymphocyte may replace tumor cells in clinical chemosensitivity test

Key words: peripheral blood lymphocyte, tumor cell, chemosenaitivity test, esophageal carcinoma

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