海滩牵牛正丁醇提取物化学成分的抗炎活性研究

doi:10.3969/j.issn.1004-616x.2015.02.015

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2015, Vol. 27 ›› Issue (2): 146-149,153.doi: 10.3969/j.issn.1004-616x.2015.02.015

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Anti-inflammatory activity of chemical components from n-butanol extract of Ipomoea stolonifera

ZHENG Fuchun¹, CHEN Yicun², QIN Yongjie², CAI Congyi^2,3

1. Department of Pharmacy, First Affiliated Hospital, Shantou University Medical College, Shantou 515041;
2. Department of Pharmacology, Medical College, Shantou University, Shantou 515041;
3. Department of Pharmacy, Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, Guangdong, China

Received:2014-12-30 Revised:2015-02-02 Online:2015-03-31 Published:2015-03-31
About author:10.3969/j.issn.1004-616x.2015.02.015

Abstract

Abstract:

OBJECTIVE:To separate and refine the chemical components from n-butanol extract of Ipomoea stolonifera (BE-IS) in Chaoshan area, and investigate their anti-inflammatory activities in vivo. METHODS:The chemical components from BE-IS were separated by different kinds of chromatography and identified by spectrum analysis methods. Then anti-inflammatory activity was evaluated in croton oil-induced ear edema model and carrageenan-induced paw edema model. RESULTS:Scopoletin, umbelliferone, esculetin, hesperetin and curcumin were extracted from BE-IS. Compared to the control group, compounds from BE-IS could inhibit the edema induced by croton oil or carrageenan to different degree, and the difference was statistically significant (P<0.01 or P<0.05). CONCLUSION: The chemical components from BE-IS have anti-inflammatoty activities, which explained why Ipomoea stolonifera possess strong anti-inflammatoty activity.

Key words: Ipomoea stolonifera, chemical components, anti-inflammatory activity, coumarin, curcumin

CLC Number:

R285

ZHENG Fuchun, CHEN Yicun, QIN Yongjie, CAI Congyi. Anti-inflammatory activity of chemical components from n-butanol extract of Ipomoea stolonifera[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2015, 27(2): 146-149,153.

References

[1] 邱华兴. 华南植物区系的评论(三)[J]. 广西植物, 1995, 15(1):7-12.
[2] 林乃洛. 民间草药田字草和白花马鞍藤的调查[J]. 中药材, 1988, 11(1):23-24.
[3] 张凤山, 聂英坤. 非甾体抗炎药[J]. 哈尔滨医科大学学报, 2002, 36(4):342-344.
[4] Hickling P, Kirwan RK, Kirwan JR. Joint destruction after glucocorticoids are withdrawn in early rheumatoid arthritis[J]. Br J Rheumatol, 1998, 37:930-936.
[5] Simon RA. Prevention and treatment of reactions to NSAIDs[J]. Clin Rev Allergy Immunol, 2003, 24(2):189-198.
[6] 杨虎天, 魏强华. 中医药治疗风湿病的进展及评述[J]. 中华风湿病学杂志, 2002, 6(6):389-391.
[7] 王晓玉, 魏伟. 抗炎免疫中药有效成分的药理学研究[J]. 中药新药与临床药理, 2006, 17(4):314-317.
[8] Cai C, Chen Y, Zhong S, et al. Anti-inflammatory activity of n-butanol extract from Ipomoea stolonifera in vivo and in vitro[J]. PLoS One, 2014, 9(4):e95931.
[9] Jones LH, Abdalla DS, Freitas JC. Effects of indole-3-acetic acid on croton oil-and arachidonic acid-induced mouse ear edema[J]. Inflamm Res, 1995, 44(9):372-375.
[10] Winter CA, Risley EA, Nuss GW. Carrageenin-induced edema in hind paw of the rat as an assay for antiinflammatory drugs[J]. Proc Soc Exp Biol Med, 1962, 111:544-547.
[11] Romero-Hernandez MA, Eguia-Aguilar P, Perezpena-DiazConti M, et al. Toxic effects induced by curcumin in human astrocytoma cell lines[J]. Toxicol Mech Methods, 2013, 23 (9):650-659.
[12] 贾淑杰, 刘庆焕, 王文彤, 等. 姜黄素、去甲氧基姜黄素和二去甲氧基姜黄素对照品的制备及姜黄素细胞毒性初步研究[J]. 中草药, 2012, 43(6):1118-1121.
[13] De Young LM, Kheifets JB, Ballaron SJ, et al. Edema and cell infiltration in the phorbol ester-treated mouse ear are temporally separate and can be differentially modulated by pharmacologic agents[J]. Agents Actions, 1989, 26(3/4): 335-341.
[14] Matsuda R, Tanihata S. Suppressive effect of sialic acid on the prostaglandin E2-mediated edema in carrageenin-induced inflammation of rat hind paws[J]. Nihon Yakurigaku Zasshi, 1992, 99(5):363-372.
[15] Kang M, Jung I, Hur J, et al. The analgesic and anti-inflammatory effect of WIN-34B, a new herbal formula for osteoarthritis composed of Lonicera japonica Thunb and Anemarrhena asphodeloides BUNGE in vivo[J]. J Ethnopharmacol, 2010, 131(2):485-496.
[16] Cabrini DA, Moresco HH, Imazu P, et al. Analysis of the potential topical anti-inflammatory activity of Averrhoa carambola L. in mice[J]. Evid Based Complement Alternat Med, 2011, 2011:908059.
[17] Antonisamy P, Duraipandiyan V, Ignacimuthu S. Anti-inflammatory, analgesic and antipyretic effects of friedelin isolated from Azima tetracantha Lam. in mouse and rat models[J]. J Pharm Pharmacol, 2011, 63(8):1070-1077.

Anti-inflammatory activity of chemical components from n-butanol extract of Ipomoea stolonifera

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