Abstract: OBJECTIVE:Safety of glutathione with vitamin C tablets was preliminarily evaluated by feeding rats with the tablets for 30 days. METHODS:Glutathione with vitamin C tablets were given 417,834,1667 mg/kg (equivalent to 25,50,100 times of the recommended dose in human) to rats for 30 days. General activities of rats were observed every day,and their body weights and food intakes were recorded every week. After 30 days,serum biochemical and hematological indexes were detected. The main organs such as liver,kidney,spleen,stomach,testis were weighed and organ coefficients were calculated,and histopatho-logical examination was performed. RESULTS:During the test,the rats were generally in good condition. Compared with the control group,the body weights of rats in the test group were not significantly abnormal (P>0.05). Results of hematology and blood biochemical indexes were within the normal range (P>0.05). There was no significant difference in organ coefficients (P>0.05) and no obvious pathological changes were found in the organs of the high-dose group. CONCLUSION:Under the experimental conditions,glutathione with vitamin C tablets had no harmful effects in rats.

Key words: glutathione, vitamin C, 30-day feeding test, safety evaluation