白介素17与上皮间质转化相关标志物在左右半结肠癌中的表达及其意义

doi:10.3969/j.issn.1004-616x.2019.04.009

Abstract

Abstract: OBJECTIVE:To investigate the expression of interleukin-17 (IL-17) and eqithelial-mesenchymal transition (EMT)-related markers in colon cancers which came from the left-and right-sides of the colon. METHODS:Expressions of IL-17 and EMT-related markers,E-cad and Vim,were determined in colon cancers and adjacent healthy tissues using qPCR. Their relationships with clinical pathological indicators of patients were also determined. RESULTS:The mRNA expression levels of IL-17 and Vim in 43 colon cancers were higher than those in normal tissues but the expression of E-cad was decreased,and the difference was statistically significant (P < 0.05). There was no significant difference in the correlation between IL-17 and EMT in colon cancers (P > 0.05). The expressions of IL-17 and EMT-related markers in colon cancer were not statistically different in gender,age,TNM stage and lymph node metastasis (P > 0.05). The mRNA expression of IL-17 was higher in left colon cancer than right colon cancer (P < 0.05),while the expression of EMT-related markers was not statistically different. CONCLUSION:IL-17 and EMT may promote the development of colon cancers but there was no correlation between them and no correlation with clinicopathological parameters. The mRNA expression of IL-17 in cancers from the left colon was higher than that in the right colon. Therefore,IL-17 may serve as one of the targets for monitoring and treatment of colon cancer (especially left colon cancer).

Key words: colon cancer, IL-17, eqithelial-mesenchymal transition, quantitative real-time PCR

CLC Number:

R735.35

LI Xinxin, LIAO Weinan, ZHUANG Shaohui, CHEN Huanjie, CHEN Juntian, ZHANG Feiran, LI Wei. Expression of interleukin-17 and EMT-related markers in colon cancers from the left-and right-sides of colons[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(4): 315-318.

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Expression of interleukin-17 and EMT-related markers in colon cancers from the left-and right-sides of colons

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