癌变·畸变·突变 ›› 1998, Vol. 10 ›› Issue (5): 304-305.doi: 10.3969/j.issn.1004-616x.1998.05.010

• 短篇报道 • 上一篇    下一篇

维生素B6 (VitB6) 对姐妹染色单体互换(SCE) 频率的影响

邓丽霞　郑履康　张　桥   

  1. 中山医科大学公共卫生学院遗传毒理研究室　广州　510089
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1998-09-30 发布日期:1998-09-30

EFFECT OF VITB6 ON FREQUENCY OF SISTER CHROMATID EXCHANGE ( SCE) IN VARIOUS CELLS BY USING IN VITRO AND IN VIVO ASSAY

Deng Lixia , Zheng Lukang , Zhang Qiao   

  1. L ab. of Genetic Toxicology , School of Public Heal th , S un Yat2Sen University of Medical Sciences , Guangz hou 　510089
  • Received:1900-01-01 Revised:1900-01-01 Online:1998-09-30 Published:1998-09-30

PDF

3018

摘要： 本文研究了维生素B6 体外体内试验对SCE 频率的影响,体外试验不同剂量VitB6 诱发中国仓鼠肺细胞株细胞(CHL) 及人周血淋巴细胞的SCE 频率显著升高( P < 0101) ,但体内试验VitB6 诱导的小鼠骨髓细胞SCE 频率与对照组比较无显著性差别( P > 0. 05) ,看来VitB6 在体内不是致突变剂。

关键词: SCE, VitB6, 体内试验, 体外试验

Abstract: The purpose of this paper is to study the effect of VitB6 on f requency of sister chromatid exchange (SCE) in cells f rom human and animals by using in Vitro and in Vivo assay. In vit ro assay , the frequency of SCE was markedly increased in both cells f rom human lymphocytes and the Chinese hamster lung cell line (CHL) , which were exposed to the VitB6 in various doses.A dose response was presented. But in Vivo assay , the statistic difference between the SCE rates of mouse bone marrow cells in test group and in that of cont rol group was not observed. In Vivo assay , it seems that the VitB6 may be not a muatgen.

Key words: Frequency of sister chromatid exchange, VitB6, In vit ro assay, In vivo assay

版权所有 ©2019 《癌变·畸变·突变》编辑部 E-mail： office@egh.net.cn
本系统由北京玛格泰克科技发展有限公司设计开发 技术支持：support@magtech.com.cn
粤ICP备 10216025号