癌变·畸变·突变 ›› 2004, Vol. 16 ›› Issue (3): 171-172.doi: 10.3969/j.issn.1004-616x.2004.03.013

• 研究简报 • 上一篇    下一篇

吲哚-3-乙酸对人外周血淋巴细胞微核和SCE频率的影响

胡晓岩,黄 辰,宋土生,王艾英   

  1. 西安交通大学医学院遗传教研室,陕西 西安 710061
  • 收稿日期:2003-06-23 修回日期:2003-09-01 出版日期:2004-05-30 发布日期:2004-05-30
  • 通讯作者: 胡晓岩

The Effect of the Indole-3-Acetic Acid on the SCE and Micronuclei of Human Peripheral Lymphocytes

HU Xiao-yan, HUANG Chen, SONG Tu-sheng, et al   

  1. The Medical School of Xi'an Jiaotong University, Xi'an 710061,China
  • Received:2003-06-23 Revised:2003-09-01 Online:2004-05-30 Published:2004-05-30
  • Contact: HU Xiao-yan

摘要: 背景与目的:研究吲哚-3-乙酸对人体外周血淋巴细胞微核和SCE频率的影响。材料与方法: 应用人体外周血淋巴细胞测定吲哚-3-乙酸诱导微核形成率试验和姊妹染色单体互换率(SCE)。结果:各吲哚-3-乙酸处理组与阴性对照组相比,微核形成率和SCE差异均存在显著性。结论:吲哚-3-乙酸对人外周血淋巴细胞的遗传物质具有损伤作用。

关键词: 吲哚-3-乙酸, 姊妹染色单体互换(SCE), 微核

Abstract: BACKGROUND & AIM: To study the effect of the indole-3-acetic acid(IAA)on the SCE and micronuclei of human peripheral lymphocytes. MATERIAL AND METHODS: We apply IAA to detect micronuclei and SCE of human peripheral lymphocytes. RESULTS: There were salience difference on the micronuclei rate and SCE rate between each group treated with different concentration of the indole-3-acetic acid and the negative controlled group(P<0.05). CONCLUSION: The indole-3-acetic acid damaged the genetic material of human peripheral lymphocytes.

Key words: Indole-3-acetic acid, SCE, micronuclei