癌变·畸变·突变 ›› 2001, Vol. 13 ›› Issue (1): 29-031.doi: 10.3969/j.issn.1004-616x.2001.01.010

• 论著 • 上一篇    下一篇

血清LDH 同工酶检测在癌症诊断上的应用

王顺祥1, 魏经建1, 王奕鹏2   

  1. WANG Shun - xiang1, WEI Jing - jian1, WANG Yi - peng2
  • 收稿日期:2000-04-26 修回日期:2000-06-15 出版日期:2001-01-30 发布日期:2001-01-30
  • 通讯作者: 王顺祥

APPLICATION OF THE SERUM LACTIC DEHYDROGENASE(LDH) AND ITS ISOENZYMES IN CARCINOMA DIAGNOSIS

11 河南省肿瘤研究所, 河南 郑州 450003; 21 郑州市金水区医院, 河南 郑州 450003   

  1. 1. Laboratory of Biochemistry, Henan Tumor Institute, Zhengzhou 450003, China; 2. Gold Water Quarter Hospital, Zhengzhou 450004, China
  • Received:2000-04-26 Revised:2000-06-15 Online:2001-01-30 Published:2001-01-30

摘要: 目的:探索血清乳酸脱氢酶同工酶在恶性肿瘤诊断上的价值。方法:血清乳酸脱氢酶总活力按崔福生介绍的方法。乳酸脱氢酶采用作者改进的琼脂糖凝胶电泳法。结果:癌症患者血清乳酸脱氢酶总活力明显增高,升高幅度为3191 %~153186 %。同工酶谱则表现为LDH1 、LDH2 减低和LDH4 、LDH5 增高趋势,并表现为LDH3 明显增高(15188 %~54151 %) 和高阳性率(71143 %~93175 %) 的特征,结论:血清乳酸脱氢酶总活力及其同工酶的检测,对恶性肿瘤的临床诊断有较高的价值。

关键词: 血清, 乳酸脱氢酶, 癌症, 诊断。

Abstract: Purpose : To explore the diagnosis value of serum lactic dehydrogenase and it s isoenzymes in carcimoma. Methods : Examination of LDH was done by CUI Fu - sheng’s method and LDH isoenzymes by agar - jelly elect rophoretogramic method. Results : Significant elevation of total LDH activity was seen in all kinds of carcinomas. The degrees of elevation was 3. 91 %~153. 86 %. Characteristic of the change in activity of LDH isoenzyme pattern was the significant elevation of LDH3 and higher positive rate (71. 43 %~93. 75 %) . LDH4 and LDH5 was raised , but LDH1 and LDH2 was declined. Conclusion : The examination of serum LDH and LDH isoenzymes has a great value in the diagnosis of carcinoma.

Key words: serum, LDH, cancer, diagnosis

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