内质网应激反应IRE1α信号通路与细胞衰老在癌症中的作用及关系的研究进展

doi:10.3969/j.issn.1004-616x.2021.01.015

癌变·畸变·突变 ›› 2021, Vol. 33 ›› Issue (1): 72-76.doi: 10.3969/j.issn.1004-616x.2021.01.015

内质网应激反应IRE1α信号通路与细胞衰老在癌症中的作用及关系的研究进展

郭茜晨, 张婷婷, 王润新, 赵法明, 盛夏

华中科技大学同济医学院公共卫生学院环境医学研究所, 湖北武汉 430030

收稿日期:2020-06-24 修回日期:2020-11-12 出版日期:2021-01-30 发布日期:2021-02-06
通讯作者: 盛夏,E-mail:xiasheng@hust.edu.cn E-mail:xiasheng@hust.edu.cn
作者简介:郭茜晨,E-mail:332314257@qq.com;张婷婷,E-mail:1010191550@qq.com。
基金资助:
国家自然科学基金青年基金（81802546）；华中科技大学自主创新基金（5003513014）

Received:2020-06-24 Revised:2020-11-12 Online:2021-01-30 Published:2021-02-06

摘要/Abstract

摘要： 肿瘤细胞常由于缺氧、营养缺乏等因素导致内质网腔内未折叠蛋白积聚，引起内质网应激，进而激活未折叠蛋白反应（UPR）以恢复细胞稳态。IRE1α-XBP1s通路作为UPR信号网络的三大分支之一，其在癌症中的作用不可小觑。近年来，随着对癌症研究的深入，发现细胞衰老所引起的细胞周期停滞，在癌症形成过程中也有着不可或缺的意义。深层次的研究表明UPR与细胞衰老之间也有着密切的关系。本综述旨在总结IRE1α信号通路在常见癌症中的作用，并深入探讨其与细胞衰老的产生在癌症发展中的相互关系，以期为癌症研究提供新思路。

关键词: 内质网应激, 未折叠蛋白反应, IRE1α信号, 癌症, 细胞衰老

中图分类号:

R730.2

郭茜晨, 张婷婷, 王润新, 赵法明, 盛夏. 内质网应激反应IRE1α信号通路与细胞衰老在癌症中的作用及关系的研究进展[J]. 癌变·畸变·突变, 2021, 33(1): 72-76.

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内质网应激反应IRE1α信号通路与细胞衰老在癌症中的作用及关系的研究进展

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