癌变·畸变·突变 ›› 2007, Vol. 19 ›› Issue (2): 113-115.doi: 10.3969/j.issn.1004-616x.2007.02.009

• 论著 • 上一篇    下一篇

NF-κB、COX-2在宫颈癌组织中的表达及其与HPV16感染的关系

林巧爱 陈向敏 夏克栋 董海燕 陈　韶 张丽芳   

  1. 1. 温州医学院微生物学与免疫学教研室, 浙江 温州　325027；2. 温州医学院生物实验中心, 浙江　温州　325027
  • 收稿日期:2006-03-22 修回日期:2006-11-15 出版日期:2007-03-30 发布日期:2007-03-30
  • 通讯作者: 林巧爱

Correlation of NF-κB and COX-2 Expressions in Cervical Cancer with HPV16 Infection

LIN Qiao-ai1, CHEN Xiang-min2, XIA Ke-dong1, DONG Hai-yan1, CHEN Shao1, ZHANG Li-fang1   

  1. 1.Department of Microbiology and Immunology, Wenzhou Medical College , Wenzhou 325027, Zhejiang,China;2. Central Laboratory of Biology, Wenzhou Medical College, Wenzhou 325027, Zhejiang, China
  • Received:2006-03-22 Revised:2006-11-15 Online:2007-03-30 Published:2007-03-30
  • Contact: LIN Qiao-ai

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摘要： 背景与目的： 探讨宫颈癌组织中NF-κB、COX-2的表达及其与HPV16感染的关系。 材料与方法： 采用免疫组织化学PowerVision TM二步法对46例宫颈癌和31例正常宫颈组织进行NF-κB、COX-2蛋白检测，用PCR技术对组织标本的HPV16 DNA进行检测。 结果： NF-κB、COX-2在宫颈癌组织中的表达率显著高于正常对照组(P<0.01)，NF-κB、COX-2的表达与HPV16型的感染具有相关性(P<0.05)。 结论： 宫颈癌组织中NF-κB、COX-2呈高表达。NF-κB的活化及COX-2的高表达可能与HPV16感染有关。

关键词: 宫颈癌, 细胞核因子κB, 环氧合酶-2, 人乳头瘤病毒16型

Abstract: BACKGROUND ＆ AIM: To explore the relationship between expressions of NF-κB and COX-2 in tissue of cervical cancer and HPV16 infection. MATERIALS AND METHODS: The expressions of NF-κB and COX-2 were assessed by immuohistochemical staining in 46 specimens of cervical cancer and 31 specimens of normal cervical tissue. The infection of HPV16 DNA were determined by PCR. RESULTS: The expression rates of NF-κB and COX-2 in cervical cancer appeared significantly higher than that in normal cervical tissue(P<0.01).The expressions of NF-κB and COX-2 in HPV DNA positive group were significantly higher than that in negative group(P<0.05) of cervical cancer. CONCLUSION: There were higher expressions of NF-κB and COX-2 in cervical carcer tissues. The activation of NF-κB and overexpression of COX-2 may be related to HPV 16 infection.

Key words: cervical cancer, NF-κB, cyclooxygenase-2, HPV16

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