多溴联苯醚的心血管毒性研究进展

doi:10.3969/j.issn.1004-616x.2022.04.013

摘要/Abstract

摘要： 多溴联苯醚(PBDEs)是一类高效溴化阻燃剂，由于其具有良好的阻燃性能、成熟的制造工艺以及低廉的价格，被广泛使用在化工纺织和电子产品等生产生活材料中。然而，PBDEs具有环境持久性和生物富集性，已成为全球性污染的可持续性有机污染物。相关研究资料显示，PBDEs对机体的心血管系统存在不同程度的毒性作用，但机制尚不明确。本文基于流行病学资料与实验室研究，通过环境暴露水平、细胞实验、动物实验以及人群研究多个层次对PBDEs的心血管毒性研究进展进行综述；同时，从细胞内活性氧激活、膜受体调节和相关通路激活等方面，概述其毒性作用机制。为了解PBDEs污染物的心血管毒性作用，尽早发现环境危险因素和人群健康问题提供参考。

关键词: 持久性有机污染物, 多溴联苯醚, 环境暴露, 心血管毒性, 毒性效应

中图分类号:

R992

邓洪齐, 郭俊恺, 刘浩, 文睿, 林桂淼. 多溴联苯醚的心血管毒性研究进展[J]. 癌变·畸变·突变, 2022, 34(4): 318-323.

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