MFSD2A在不同生理病理状态下的作用和机制研究进展

doi:10.3969/j.issn.1004-616x.2022.05.013

癌变·畸变·突变 ›› 2022, Vol. 34 ›› Issue (5): 404-407.doi: 10.3969/j.issn.1004-616x.2022.05.013

• 综述 • 上一篇

MFSD2A在不同生理病理状态下的作用和机制研究进展

马晟, 肖汀

国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院, 分子肿瘤学国家重点实验室, 癌发生及预防分子机理北京市重点实验室, 北京 100021

收稿日期:2022-03-27 修回日期:2022-08-05 发布日期:2022-10-09
通讯作者: 肖汀
作者简介:马晟,E-mail:shengma@student.pumc.edu.cn。
基金资助:
中国医学科学院医学与健康科技创新工程(2021-1-12M-050)

Received:2022-03-27 Revised:2022-08-05 Published:2022-10-09

摘要/Abstract

摘要： 主要促进因子超家族成员2a(MFSD2A)属于主要协同转运蛋白超家族成员，是一种钠依赖性溶血磷脂酰胆碱(LPC)同向转运蛋白，将二十二碳六烯酸(DHA)通过血脑屏障转运进入大脑，并抑制脑血管上皮细胞的胞吞作用，以此形成血脑屏障的低通透性，这些重要的功能使得MFSD2A基因受到了广泛的关注。近些年来的研究表明，MFSD2A在血脑屏障形成、DHA转运、胎盘发育、肝细胞再生、棕色脂肪代谢等生理过程中起到关键作用，在阿尔茨海默病、糖尿病视网膜病变、肿瘤发生等疾病进展中起到重要的调控作用。因此，本文结合近期的研究，对MFSD2A基因在生理病理过程中的作用及其机制研究进行总结。

关键词: 主要促进因子超家族成员2a, 血脑屏障, DHA转运, 生理作用, 病理机制, MFSD2A

中图分类号:

R730.23

马晟, 肖汀. MFSD2A在不同生理病理状态下的作用和机制研究进展[J]. 癌变·畸变·突变, 2022, 34(5): 404-407.

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MFSD2A在不同生理病理状态下的作用和机制研究进展

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