饮用水中微塑料污染及其对健康的损害效应的研究进展

doi:10.3969/j.issn.1004-616x.2025.01.014

摘要/Abstract

摘要： 近年来，塑料制品得到广泛使用，而释放到环境中的塑料难以降解，可在水环境等介质中长期存在。在外界条件的影响下，这些塑料会形成小的碎片，其中粒径小于5 mm的颗粒称为微塑料。微塑料的全球性污染受到普遍关注，饮用水中的微塑料污染形势不容乐观，可能会损害人体健康。研究发现微塑料对不同的生物体产生了不同的毒理学效应，包括氧化应激、炎症反应、破坏肠道微生物和生殖毒性等。本文对国内外饮用水中微塑料污染的现状及其对健康的损害、微塑料对机体毒性的作用机制进行综述，以期为微塑料毒性作用的进一步研究提供参考。

关键词: 微塑料, 饮用水, 健康损害, 毒性

中图分类号:

R994.6

武新月, 梁婕, 张薇, 卞倩. 饮用水中微塑料污染及其对健康的损害效应的研究进展[J]. 癌变·畸变·突变, 2025, 37(1): 81-84,89.

参考文献

[1] SHI R Y, LIU W T, LIAN Y H, et al. Phytotoxicity of polystyrene, polyethylene and polypropylene microplastics on toma to (Lycopersicon esculentum L.)[J]. J Environ Manage, 2022, 317: 115441.
[2] AHMAD F, CAO W T, ZHANG Y N, et al. Oil recovery from microwave co-pyrolysis of polystyrene and polypropylene plastic particles for pollution mitigation[J]. Environ Pollut, 2024, 356: 124240.
[3] ACARER S. Abundance and characteristics of microplastics in drinking water treatment plants, distribution systems, water from refill kiosks, tap waters and bottled waters[J]. Sci Total Environ, 2023, 884: 163866.
[4] ULLAH S, AHMAD S, GUO X L, et al. A review of the endocrine disrupting effects of micro and nano plastic and their associated chemicals in mammals[J]. Front Endocrinol, 2023, 13: 1084236.
[5] D-BROWSKA A, MIELA-CZUK M, SYCZEWSKI M. The Raman spectroscopy and SEM/EDS investigation of the primary sources of microplastics from cosmetics available in Poland[J]. Chemosphere, 2022, 308(Pt 3): 136407.
[6] XIA B, SUI Q, DU Y S, et al. Secondary PVC microplastics are more toxic than primary PVC microplastics to Oryzias melastigma embryos[J]. J Hazard Mater, 2022, 424(Pt B): 127421.
[7] ZHANG N, LI Y B, HE H R, et al. You are what you eat: microplastics in the feces of young men living in Beijing[J]. Sci Total Environ, 2021, 767: 144345.
[8] PIVOKONSKY M, CERMAKOVA L, NOVOTNA K, et al. Occurrence of microplastics in raw and treated drinking water[J]. Sci Total Environ, 2018, 643: 1644-1651.
[9] WANG Z F, LIN T, CHEN W. Occurrence and removal of microplastics in an advanced drinking water treatment plant (ADWTP)[J]. Sci Total Environ, 2020, 700: 134520.
[10] O-MANN B E, SARAU G, HOLTMANNSP-TTER H, et al. Small-sized microplastics and pigmented particles in bottled mineral water[J]. Water Res, 2018, 141: 307-316.
[11] MINTENIG S M, L-DER M G J, PRIMPKE S, et al. Low numbers of microplastics detected in drinking water from ground water sources[J]. Sci Total Environ, 2019, 648: 631-635.
[12] FU Z L, WANG J. Current practices and future perspectives of microplastic pollution in freshwater ecosystems in China[J]. Sci Total Environ, 2019, 691: 697-712.
[13] MASON S A, WELCH V G, NERATKO J. Synthetic polymer contamination in bottled water[J]. Front Chem, 2018, 6: 407.
[14] SCHYMANSKI D, GOLDBECK C, HUMPF H U, et al. Analysis of microplastics in water by micro-Raman spectroscopy: release of plastic particles from different packaging into mineral water[J]. Water Res, 2018, 129: 154-162.
[15] LIU S, LI H, WANG J, et al. Polystyrene microplastics aggravate inflammatory damage in mice with intestinal immune imbalance[J]. Sci Total Environ, 2022, 833: 155198.
[16] STOCK V, B-HMERT L, LISICKI E, et al. Uptake and effects of orally ingested polystyrene microplastic particles in vitro and in vivo[J]. Arch Toxicol, 2019, 93(7): 1817-1833.
[17] VENEMAN W J, SPAINK H P, BRUN N R, et al. Pathway analysis of systemic transcriptome responses to injected polystyrene particles in zebrafish larvae[J]. Aquat Toxicol, 2017, 190: 112-120.
[18] LIU Z Q, YU P, CAI M Q, et al. Effects of microplastics on the innate immunity and intestinal microflora of juvenile Eriocheir sinensis[J]. Sci Total Environ, 2019, 685: 836-846.
[19] TANG J, NI X Z, ZHOU Z, et al. Acute microplastic exposure raises stress response and suppresses detoxification and immune capacities in the scleractinian coral Pocillopora damicornis[J]. Environ Pollut, 2018, 243(Pt A): 66-74.
[20] LI B Q, DING Y F, CHENG X, et al. Polyethylene microplastics affect the distribution of gut microbiota and inflammation development in mice[J]. Chemosphere, 2020, 244: 125492.
[21] QIAO R X, SHENG C, LU Y F, et al. Microplastics induce intestinal inflammation, oxidative stress, and disorders of metabolome and microbiome in zebrafish[J]. Sci Total Environ, 2019, 662: 246-253.
[22] OU S W, CHEN H P, WANG H F, et al. Fusobacterium nucleatum upregulates MMP7 to promote metastasis-related characteristics of colorectal cancer cell via activating MAPK(JNK)-AP1 axis[J]. J Transl Med, 2023, 21(1): 704.
[23] RICHARDSON M, REN J H, RUBINSTEIN M R, et al. Analysis of 16S rRNA genes reveals reduced Fusobacterial community diversity when translocating from saliva to GI sites[J]. Gut Microbes, 2020, 12(1): 1-13.
[24] WAN Z Q, WANG C Y, ZHOU J J, et al. Effects of polystyrene microplastics on the composition of the microbiome and metabolism in larval zebrafish[J]. Chemosphere, 2019, 217: 646-658.
[25] LU L, WAN Z Q, LUO T, et al. Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice[J]. Sci Total Environ, 2018, 631/632: 449-458.
[26] HOU J Y, LEI Z M, CUI L L, et al. Polystyrene microplastics lead to pyroptosis and apoptosis of ovarian granulosa cells via NLRP3/Caspase-1 signaling pathway in rats[J]. Ecotoxicol Environ Saf, 2021, 212: 112012.
[27] HU Y, JIANG S Y, ZHANG Q, et al. Protective effect of Cordycepin on blood-testis barrier against pre-puberty polystyrene nanoplastics exposure in male rats[J]. Part Fibre Toxicol, 2024, 21(1): 30.
[28] PACHECO A, MARTINS A, GUILHERMINO L. Toxicological interactions induced by chronic exposure to gold nanoparticles and microplastics mixtures in Daphnia magna[J]. Sci Total Environ, 2018, 628/629: 474-483.
[29] MARTINS A, GUILHERMINO L. Transgenerational effects and recovery of microplastics exposure in model populations of the freshwater cladoceran Daphnia magna Straus[J]. Sci Total Environ, 2018, 631/632: 421-428.
[30] DING J N, ZHANG S S, RAZANAJATOVO R M, et al. Accumulation, tissue distribution, and biochemical effects of polystyrene microplastics in the freshwater fish red Tilapia (Oreochromis niloticus)[J]. Environ Pollut, 2018, 238: 1-9.
[31] MAGNI S, GAGNé F, ANDRé C, et al. Evaluation of uptake and chronic toxicity of virgin polystyrene microbeads in freshwater Zebra mussel Dreissena polymorpha (Mollusca: Bivalvia)[J]. Sci Total Environ, 2018, 631/632: 778-788.
[32] MAK C W, CHING-FONG YEUNG K, CHAN K M. Acute toxic effects of polyethylene microplastic on adult zebrafish[J]. Ecotoxicol Environ Saf, 2019, 182: 109442.
[33] BARBOZA L G A, VIEIRA L R, BRANCO V, et al. Microplastics cause neurotoxicity, oxidative damage and energy-related changes and interact with the bioaccumulation of mercury in the European seabass, Dicentrarchus labrax (Linnaeus, 1758)[J]. Aquat Toxicol, 2018, 195: 49-57.
[34] SARASAMMA S, AUDIRA G, SIREGAR P, et al. Nanoplastics cause neurobehavioral impairments, reproductive and oxidative damages, and biomarker responses in zebrafish: throwing up alarms of wide spread health risk of exposure[J]. Int J Mol Sci, 2020, 21(4): 1410.
[35] MURALI K, KENESEI K, LI Y, et al. Uptake and bio-reactivity of polystyrene nanoparticles is affected by surface modifications, ageing and LPS adsorption: in vitro studies on neural tissue cells[J]. Nanoscale, 2015, 7(9): 4199-4210.
[36] URBINA M A, DA SILVA MONTES C, SCH-FER A, et al. Slow and steady hurts the crab: effects of chronic and acute microplastic exposures on a filter feeder crab[J]. Sci Total Environ, 2023, 857(Pt 1): 159135.
[37] SUSSARELLU R, SUQUET M, THOMAS Y, et al. Oyster reproduction is affected by exposure to polystyrene microplastics[J]. Proc Natl Acad Sci USA, 2016, 113(9): 2430-2435.
[38] DENG Y F, ZHANG Y, LEMOS B, et al. Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure[J]. Sci Rep, 2017, 7: 46687.
[39] JIN Y X, LU L, TU W Q, et al. Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice[J]. Sci Total Environ, 2019, 649: 308-317.
[40] KHALID N, AQEEL M, NOMAN A, et al. Linking effects of microplastics to ecological impacts in marine environments[J]. Chemosphere, 2021, 264(Pt 2): 128541.
[41] NAIK R K, NAIK M M, D’COSTA P M, et al. Microplastics in ballast water as an emerging source and vector for harmful chemicals, antibiotics, metals, bacterial pathogens and HAB species: a potential risk to the marine environment and human health[J]. Mar Pollut Bull, 2019, 149: 110525.
[42] JAFFER Y D, ABDOLAHPUR MONIKH F, ULI K, et al. Tire wear particles enhance horizontal gene transfer of antibiotic resistance genes in aquatic ecosystems[J]. Environ Res, 2024, 263(Pt 3): 120187.
[43] QIN J, XIA P F, YUAN X Z, et al. Chlorine disinfection elevates the toxicity of polystyrene microplastics to human cells by inducing mitochondria-dependent apoptosis[J]. J Hazard Mater, 2022, 425: 127842.