衰老肿瘤相关成纤维细胞及其在肿瘤进展中的作用

doi:10.3969/j.issn.1004-616x.2025.04.013

癌变·畸变·突变 ›› 2025, Vol. 37 ›› Issue (4): 308-309,335.doi: 10.3969/j.issn.1004-616x.2025.04.013

• 专题研究 • 上一篇

衰老肿瘤相关成纤维细胞及其在肿瘤进展中的作用

冯英瑛, 肖汀, 冯林

国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院, 分子肿瘤学全国重点实验室, 病因及癌变研究室, 北京 100021

收稿日期:2025-04-23 修回日期:2025-05-27 发布日期:2025-08-05
通讯作者: 冯林
作者简介:冯英瑛，E-mail：s2023003005@pumc.edu.cn。
基金资助:
国家自然科学基金(82372718)；中国医学科学院医学与健康科技创新工程(2021-I2M-1-050)

Senescent tumor-associated fibroblasts and their role in tumor progression

FENG Yingying, XIAO Ting, FENG Lin

Received:2025-04-23 Revised:2025-05-27 Published:2025-08-05

摘要/Abstract

摘要： 衰老肿瘤相关成纤维细胞(senCAF)作为肿瘤微环境的重要组成部分，因其分泌衰老相关分泌表型(SASP)因子，如IL-6、IL-8和基质金属蛋白酶(MMP)等，促进肿瘤细胞的增殖、侵袭和免疫抑制。此外，senCAF还能增强肿瘤对化疗、放疗和免疫治疗的耐受性，使传统疗法的抗癌效果降低。本文围绕senCAF的分子特征、诱导因素及其在肿瘤进展中的作用进行综述。

中图分类号:

R730.2

冯英瑛, 肖汀, 冯林. 衰老肿瘤相关成纤维细胞及其在肿瘤进展中的作用[J]. 癌变·畸变·突变, 2025, 37(4): 308-309,335.

FENG Yingying, XIAO Ting, FENG Lin. Senescent tumor-associated fibroblasts and their role in tumor progression[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2025, 37(4): 308-309,335.

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衰老肿瘤相关成纤维细胞及其在肿瘤进展中的作用

Senescent tumor-associated fibroblasts and their role in tumor progression

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