癌变·畸变·突变 ›› 2026, Vol. 38 ›› Issue (1): 71-74.doi: 10.3969/j.issn.1004-616x.2026.01.012

• 检测硏究 • 上一篇    

西洋参黄芪组合物的抗疲劳作用研究

王志鹏, 李梅, 李建国, 李建华, 尹晶晶, 刘欢   

  1. 中国辐射防护研究院药物安全性评价中心, 中国核工业集团有限公司放射毒理与放射性药物临床前评价重点实验室, 药物毒理及放射性药物临床前研究山西省重点实验室, 国家原子能机构核技术(放射性药物非临床评价)研发中心, 山西 太原 030006
  • 收稿日期:2025-10-09 修回日期:2025-11-13 发布日期:2026-01-30
  • 通讯作者: 刘欢

Study on anti-fatigue effect from American ginseng and astragalus

WANG Zhipeng, LI Mei, LI Jianguo, LI Jianhua, YIN Jingjing, LIU Huan   

  1. Drug Safety Evaluation Center of China Institute for Radiation Protection, China National Nuclear Corporation Key Laboratory on Radiotoxicology and Radiopharmaceutical Preclinical Evaluation, Shanxi Key Laboratory of Drug Toxicology and Drug for Radiation Injury, National Atomic Energy Authority Nuclear Technology (Non-clinical Evaluation of Radiopharmaceuticals) Research and Development Center, Taiyuan 030006, Shanxi, China
  • Received:2025-10-09 Revised:2025-11-13 Published:2026-01-30

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摘要： 目的： 研究不同剂量的西洋参黄芪组合物在抗疲劳方面的协调作用及优势，筛选出有显著抗疲劳作用的剂量。方法： 将西洋参、黄芪按照1∶3经水提醇沉后取沉淀，干燥获取中药提取物。将提取物按高、中、低剂量(分别为600、300、150 mg/kg)连续灌胃给予小鼠30 d，另设空白对照组和阳性对照组。采用乳酸清除率试验，运动后血清中尿素氮和肌酸激酶含量测定，肝糖原含量测定及负重游泳试验中相关指标的变化来判断不同剂量受试物组动物的耐疲劳性。结果： 与空白对照组比较，各受试物组能够使小鼠血乳酸曲线下面积降低，肝糖原含量增加，运动后机体血清尿素氮与肌酸激酶水平降低，负重游泳试验中的力竭时间增加(P<0.05或P<0.01)。与阳性对照组比较，高剂量组受试物组小鼠血乳酸曲线下面积降低，肝糖原含量增加(P<0.05)。结论： 西洋参黄芪组合物对小鼠有抗疲劳作用且高剂量组抗疲劳效果优于阳性对照物。

关键词: 西洋参, 黄芪, 抗疲劳, 小鼠

Abstract: OBJECTIVE： To study synergistic anti-fatigue effect of different doses and combinations of American ginseng and astragalus，and to screen out the dose with significant anti-fatigue effect. METHODS： American ginseng and astragalus were extracted with water and precipitated with alcohol at a ratio of 1∶3， and the precipitate was dried to obtain the herbal extract. The extract was administered to mice by gavage at high，medium，and low doses (600，300，and 150 mg/kg，respectively) for 30 days. A blank control group and a positive control group were also set up. The fatigue resistance of animals in different dose groups was judged by lactate clearance rate test， serum urea nitrogen and creatine kinase content after exercise， liver glycogen content，and changes in related indicators in the weighted swimming test. RESULTS： Compared with the blank control group，each test group showed a reduced area under the curve of serum lactate，increased liver glycogen content， reduced serum urea nitrogen and creatine kinase levels after exercise and increased time to exhaustion in the weighted swimming test (P<0.05 or P<0.01). Compared with the positive control group， the area under the curve (AUC) of blood lactate and the liver glycogen content of mice in the high-dose test substance group were decreased (P<0.01). CONCLUSION： The American ginseng and astragalus combination had an anti-fatigue effect on mice，and the high-dose group has a better anti-fatigue effect than the positive control.

Key words: American ginsengt, astragalus, anti-fatigue, mice

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