Abstract: Abstract 　The influences of calmodulin antagonist CPZ , and calcium channel blocker NIMO and the combination on cadmiumpoisoning of mice were studied. Animal models for cadmiumpoisoning were established by peritoneal injection of 1/ 5 LD50CdCl2 , The experimental groups were protected by administering of CPZ、NIMO and combination of CPZ and NIMO respectively one hour before the injection of CdCl2 . Five consecutive days later , samples were collected for analysis. The data showed that the Cd content in blood and the urinaryγ2GT and NAG activities were reduced significantly by CPZ. Both CPZ and NIMO showed considerable protective effect against the decrease of Ca2 + - Mg2 + - ATPase activity , and a remarkable synergistic action between them was observed. Both CPZ and NIMO could considerably increase MT contents in livers and kidneys of Cd poisonig mice. The results indicated that the inhibitors could protect mice against the toxic effects of Cd on liver and kidney , while CPZ was more efficient than NIMO. The combination of CPZ and NIMO could exert a synergistic action in some aspects. The protective action of these two drugs might be relevent to the function of MT.

Key words: Key words 　Cadmium poisoning, Chloropazine (CPZ), Nimodipine (NIMO), Cadmiummetallothionein(Cd - MT)