萌动激活赤灵芝孢子粉致畸、致突变和抗突变的实验研究①

doi:10.3969/j.issn.1004-616x.2002.03.013

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2002, Vol. 14 ›› Issue (3): 183-185.doi: 10.3969/j.issn.1004-616x.2002.03.013

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STUDY OF THE GERMINATION ACTIVATED GANODERMA SPORES ON TERATOGENICITY , MUTAGENICITY AND ANTIMUTAGENICITY

DENG Li-xia1, Hu Bin1, CHEN Xiao-jun2, CHEN Tie-jiang1, GUN De-xiu1, ZHENG Lü-quan1

1. Department of Toxicology, School of Public Health, Zhong shan University; 2.Tumor Research Institute, Zhong shan University, Guang Zhou 　510089, China

Received:2001-11-22 Revised:2002-04-05 Online:2002-07-30 Published:2002-07-30
Contact: DENG Li-xia1

Abstract

Abstract: Purpose and Methods : To analyse the effect s of the Ganoderma spores on teratogenicity , mutagenicity and anti2mutagenicity by the test of teratogenesis in rat s and of chromosome aberration(CA) analysis in bone marrow cells of mice. Results : ①The rate of CA in mice induced by the spores had no significant difference as compared with the negative cont rol group ( P > 0. 05) . ②It did not show the development toxicity in the development of embryos after t reatment of the spores. ③Germination activated ganoderma spores could significantly depress the rate of CA induced by CP(40 mg/ kg and 50 mg/ kg) . The depression rate of CA induced by CP(50 mg/ kg) was above 52. 0 % and showed dose2response. Conclusion : Germination activated ganoderma spores had no effect s of teratogenicity and chromosome damage , and it possesses the antagonistic or protective effect to the chromosome damage.

Key words: germination activated/ ganoderma spores, teratogenicity, mutagenicity, antimutagenicity

CLC Number:

R28 R965. 2

DENG Li-xia, Hu Bin, CHEN Xiao-jun, CHEN Tie-jiang, GUN De-xiu, ZHENG Lü-quan. STUDY OF THE GERMINATION ACTIVATED GANODERMA SPORES ON TERATOGENICITY , MUTAGENICITY AND ANTIMUTAGENICITY[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2002, 14(3): 183-185.

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STUDY OF THE GERMINATION ACTIVATED GANODERMA SPORES ON TERATOGENICITY , MUTAGENICITY AND ANTIMUTAGENICITY

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