桑椹对小鼠骨髓细胞诱发突变的抑制作用

doi:10.3969/j.issn.1004-616x.1998.02.011

Carcinogenesis, Teratogenesis & Mutagenesis ›› 1998, Vol. 10 ›› Issue (2): 104-107.doi: 10.3969/j.issn.1004-616x.1998.02.011

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INHIBITORY EFFECT OF MULBERRY ON MUTATION OF MARROW CELLS INDUCED BY CYCLOPHOSPHAMIDE IN MOUSE

J iang Shengyang1 　Zhuangxun2

1 Department of Heal th Toxicology , 2 Department of Epidemiology Nantong Medical College Nantong 226001

Received:1900-01-01 Revised:1900-01-01 Online:1998-03-30 Published:1998-03-30

Abstract

Abstract: The micronucleus assay in mouse marrow PCE and chromosome aberration assay in mouse marrow cells have been used to investigate the inhibitory effect of flesh mulberry juice on mutation rate that was enhanced by cyclophosphamide. The result s showed that the flesh mulberry juice can significantly reduced the PCE micronucleus rate and chromosome aberration rate that was enhanced by the cyclophosphamide in mouse marrow ( P < 0. 05 or P < 0. 01) . It also showed that these effect s have well dose - effect dependent relationship. The relative coefficient is - 0. 94 and - 0. 98.

Key words: Mulberry, Cyclophosphamide, PCE micronucleus, Chromosomes aberration, Mouse

J iang Shengyang 　Zhuangxun. INHIBITORY EFFECT OF MULBERRY ON MUTATION OF MARROW CELLS INDUCED BY CYCLOPHOSPHAMIDE IN MOUSE[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1998, 10(2): 104-107.

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INHIBITORY EFFECT OF MULBERRY ON MUTATION OF MARROW CELLS INDUCED BY CYCLOPHOSPHAMIDE IN MOUSE

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