人肺癌组织DNA - 蛋白质交联物的初步探讨

doi:10.3969/j.issn.1004-616x.1999.05.002

Carcinogenesis, Teratogenesis & Mutagenesis ›› 1999, Vol. 11 ›› Issue (5): 216-218.doi: 10.3969/j.issn.1004-616x.1999.05.002

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A PRIMARY STUDY ON THE FORMATION OF DNA2PROTEIN CROSSLINKS IN HUMAN LUNG CANCER TISSUE

Lei Yixiong , Yi Fei , Chen J iakun

Guangz hou Instit ute f or Chemical Carcinogenesis , Guangz hou Medical College , Guangz hou 　510182

Received:1999-03-18 Revised:1999-06-24 Online:1999-09-30 Published:1999-09-30

Abstract

Abstract: In other to investigate the relationship between DNA2protein crosslinks (DPC) and human lung cancer , we have used a sensitive 125Ⅰ2postlabelling assay to detect the formation of DPC in tissues to various cell type of human lung cancer. The results were showed that DPC was increased in lung cancer tissues comparing with its neighbored normal tissues , suggesting that DPC may play a part in the development of lung cancer. No significance differences were observed in DPC of tissues between adenocarcinoma and epidermoid carcinoma , and in DPC of lung cancer tissus between smoker and non2smoker.

Key words: DNA-protein crosslinks, lung cancer, smoking

Lei Yixiong , Yi Fei , Chen J iakun. A PRIMARY STUDY ON THE FORMATION OF DNA2PROTEIN CROSSLINKS IN HUMAN LUNG CANCER TISSUE[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1999, 11(5): 216-218.

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A PRIMARY STUDY ON THE FORMATION OF DNA2PROTEIN CROSSLINKS IN HUMAN LUNG CANCER TISSUE

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