甲氨基阿维菌素的致突变性、致畸性及亚慢性毒性的研究

doi:10.3969/j.issn.1004-616x.2000.03.010

Abstract

Abstract: Purpose and Methods : Mutagenicity , teratogenicity and subchronic toxicity in mice or rat s induced by Methylamino2Abamectin (MA) were studied. Results and Conclusion : In comparison with negative cont rol , each dosage did not show significant differences in the rates of marrow cell micronuclei and spermatic deformity of mice ( P > 0. 05) ; but revealed significant difference compared to positive cont rol ( P < 0. 05) . MA (102500μg/ plate) didn’t induce positive mutations of st rains TA97 ,TA98 ,TA100 and TA102 with or without S9mix n Ames test . It suggested that MA has no obvious mutagenicity and embryotoxic or teratogenic effects in Wistar rats. At the highest dosage , BUN and Albumin at 12. 6mg/ kg. bw in females showed significant diffence ( P <0. 05) , so did BUN at 9. 26mg/ kg. bw in males ( P < 0. 05) . Body weight s were decreased in males and organ coefficient of kidney was increased in males ad females. The maximum no2observed2effect level of MA in subchromic toxicity was 1. 16mg/ kg. bw and 1. 57mg/ kg. bw in males and females , respectively.

Key words: Methylamino-Abamectin (MA), mutagenicity, subchronic toxicity, teratogenicity.

CLC Number:

Q355

XING Cai-hong , DAI Yu-fei , CHANG Ping , et al. STUDIES ON THE MUTAGENICITY , TERATOGENICITY AND SUBCHRONIC TOXICITY OF METHYLAMINO-ABAMECTIN[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2000, 12(3): 156-161.

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STUDIES ON THE MUTAGENICITY , TERATOGENICITY AND SUBCHRONIC TOXICITY OF METHYLAMINO-ABAMECTIN

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