Carcinogenesis, Teratogenesis & Mutagenesis ›› 2002, Vol. 14 ›› Issue (4): 210-213.doi: 10.3969/j.issn.1004-616x.2002.04.002

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EFFECT OF IMIDACLOPRID AND RH25849 ON GENETIC MATERIAL OF HUMAN PERIPHERAL LYMPHOCYTES

FENG Shao-long1, KONG Zhi-ming2, WANG Wu-xiang3, WANG Xing-ming1, PENG Ping-an1   

  1. 1. The State Key Laboratory of Organic Geochemistry, Chinese Academy of Sciences Guangzhou Institue of Geochemistry, Guangzhou 510640, China; 2. The State Key Laboratory of Pollution Control and Resource Reuse, the School of Environment, Nanjing University, Nanjing 210093, China; 3. The Refresher School of teacher in Hengnan Country, Hengyang 421141, China
  • Received:2002-03-12 Revised:2002-05-29 Online:2002-10-30 Published:2002-10-30

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Abstract: Purpose : To study the effect s of the two new-type pesticides , imidacloprid and RH25849 , on the DNA of human peripheral lymphocytes. Methods : Micronuclei test , SCE test and comet assay were employed in the experiment . Results : At the low dose (imidacloprid 0. 05 mg/ L and RH25849 5 mg/ L) , there were no effect on the micronuclei rate and the SCE rate , compared with the negative cont rolled groups ( P > 0. 05) . But there were adverse effect s when the dose increased , and the difference was significant as compared with the negative cont rol groups ( P < 0. 05) . In the comet assay , starting f rom the lowest dose the two pesticides caused DNA damages in the human peripheral lymphocytes as compared with the cont rol groups , and the differences were significant ( P < 0. 01) , and there were dose dependent relationship ( r = 0. 995 , r = 0. 965) . ConclusionBoth imidacloprid and RH-5849 damaged the DNA of human peripheral lymphocytes. Comparatively. Imidacloprid was more toxic than RH25849.

Key words: micronuclei, SCE, comet test, imidacloprid : RH-5849

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