Carcinogenesis, Teratogenesis & Mutagenesis ›› 2003, Vol. 15 ›› Issue (1): 25-27.doi: 10.3969/j.issn.1004-616x.2003.01.007

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ESTABLISHMENT OF IMMUNE TOLERANCE MODEL IN BALB/C MOUSE AND PRELIMINARY STUDY ON THE TRANSPLANTING HUMAN LUNG CANCER

REN Jin-rong, ZHENG Zhen-hai, WANG Zeng-lin, LIU Lu-ning, YU Feng-ling   

  1. 1. Hebei Cancer Institute The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011 , China; 2. Hebei lingshou Zheng's Bialogcal Cancer Institute, Linshou County 050500 , China
  • Received:2001-09-21 Revised:2002-07-10 Online:2003-01-30 Published:2003-01-30
  • Contact: REN Jin-rong

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Abstract: Purpose: To obtain an animal model in which the human lung tumor may successfully be transplanted and survival. Methods: In new born BALB / C mice the immune tolerance was induced by injecting Zheng's plant-protein (ZPP), and then the human lung tumor tissues were transplanted into the mice. Results: 65 ％ (26 / 40) of the transplanted human lung tumor tissues were survival whereas in the control mice the transplanted tumors were totally rejected. Conclusion: ZPP may induce immune tolerance in BALB / C mouse and the transplanted human lung cancer may be survival in the mouse.

Key words: BALB/C mice, Immune tolerance, Lung tumor, Transplanting, Zheng's plant protein