Carcinogenesis, Teratogenesis & Mutagenesis ›› 2003, Vol. 15 ›› Issue (4): 205-208.doi: 10.3969/j.issn.1004-616x.2003.04.005

Previous Articles     Next Articles

EFFECTS OF AC-88 ON TNF-α、 IL-1β、 IL-6 mRNA CONTENTS AND PROLIFERATION OF T LYMPHOCYTE IN TUMOUR BEARING MICE

MA Dong-zhu, SUN Ke-ren, ZHAO Li, et al   

  1. Department of Toxicology, Shandong University, Jinan 250012, China
  • Received:2002-12-10 Revised:2003-03-03 Online:2003-10-30 Published:2003-10-30
  • Contact: MA Dong-zhu

PDF (PC)

2512

Abstract: Purpose: To investigate the antitumor effect and possible mechanism of AC-88. Methods: Tumor bearing mice were used as model in vivo to study the an titumor effect of AC-88. T cell proliferation was determined by using MTT method. The changes of TNF-α、 IL-1β、 IL-6 mRNA content in T cells were measured by RT-PCR. Results: The antitumor rate of AC-88 was 76 ％. Treatmemt with AC-88 significantly enhanced T cell proliferation, and increased contents of TNF-α,IL-1β,IL-6 mRNA in T cells by 2-4 folds compared with that in control(P< 0.01) . Conclusions: AC-88 can inhibit the growth of tumor and regulate the T cell function in tumor bearing mice, which is worthy to be developed into an anticarcinogen.

Key words: AC-88, cytokine, TNF -α, IL-1β, IL-6, T cell proliferation