Carcinogenesis, Teratogenesis & Mutagenesis ›› 2004, Vol. 16 ›› Issue (1): 43-45.doi: 10.3969/j.issn.1004-616x.2004.01.013

Previous Articles     Next Articles

Anti-mutagenicity test of PS8812 Polysaccharides and its Selenium Polysaccharides

ZHANG Quan-xin;NIE Mu-hai   

  1. Department of Toxicology, Guangzhou Center for Diseases Prevention and control,Guangzhou 510080 , China
  • Received:2003-03-03 Revised:2003-04-30 Online:2004-01-30 Published:2004-01-30
  • Contact: ZHANG Quan-xin

PDF (PC)

3100

Abstract: BACKGROUND＆AIM: To study the antimutagenic effect of PS8812 Polysaccharides (PSP) and its Selenium Polysaccharides(PSSP).MATERIAL AND METHODS: The Ames test,mouse marrow micronucleus test and mouse sperm malformation test were used. RESULTS: PSP and PSSP both could evidently inhibit the reverse mutation on Salmonella thphimurium strains TA98 and TA100 with and without S9 mix.The rates of maximum inhibition were 65.39 ％ and 73.21 ％ respectively.The frequencies of micronucleus and abnormal sperms induced by cyclophosphamide (CP)were reduced significantly by PSP and PSSP.The inhibitory rate of micronucleus was between 40.24 ％ and 60.37 ％; the inhibitory rate of abnormal sperms was between 38.92 ％ and 62.36 ％.CONCLUSION: PSP and PSSP have significant antimutagenic effect.

Key words: polysa ccharides, selenium polysaccharides, ant- imutagenicity