Carcinogenesis, Teratogenesis & Mutagenesis ›› 2004, Vol. 16 ›› Issue (4): 206-207.doi: 10.3969/j.issn.1004-616x.2004.04.005

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Effect of Grape Procyanidin on Bcl-2 and Bax Expression of Bone Marrow Cell

SUI Ping，LIU Hai-zhen，ZHONG Jin-yi   

  1. Medical College of Qingdao University,Qingdao 266021,China
  • Received:2004-02-08 Revised:2004-05-12 Online:2004-07-30 Published:2004-07-30
  • Contact: ZHONG Jin-yi

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Abstract: BACKGROUND ＆ AIM: To study the effect of grape procyanidin (GPC) on Bcl-2 and Bax expression of the bone marrow cells. MATERIAL AND METHODS: The mice given different dose of GPC were exposed to 60Co r-rays whole body subacutely.The Bcl-2 and Bax expression of mice bone marrow cells was measured by immunohistochemistry method. RESULTS: The expression rates of Bcl-2 and Bax of the irradiating control group were 10.02 ％and 20.88 ％ respectively,and those of the high dose GPC group were 18.28 ％ and 16.14 ％.The differences between the two groups were significant(P<0.01). CONCLUSION: GPC can inhibit the abnormal expression of Bcl-2 and Bax induced by 60Co γ-rays radiation.

Key words: procyanidin, bone marrow cell, Bcl-2, Bax, radiation injury