硝酸羟胺急性毒性和诱导染色体损伤的初步研究

doi:10.3969/j.issn.1004-616x.2004.06.013

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2004, Vol. 16 ›› Issue (6): 359-361.doi: 10.3969/j.issn.1004-616x.2004.06.013

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Study on the Acute Toxicity and the Genetic Damage of Chromosome in Mice After Exposure to Hydroxylammonium Nitrate

JIA Qing-jun, YANG Lu-jun, LIU Jin-yi, et al

Department of Hygienic Toxicology,Preventive Medicine College,Third Millitary Medical University,Chongqing 400038, China

Received:2004-06-15 Revised:2004-08-10 Online:2004-11-30 Published:2004-11-30
Contact: CAO Jia

Abstract

Abstract: BACKGROUND ＆ AIM: To explore the acute toxicity and LD50,and study the genetic damage of bone marrow cells induced by Hydroxylammonium Nitrate. MATERIAL AND METHODS: After celiac administration of HAN in mice,the mortality and the physiological changes were observed; Chromosome aberration test,micronucleus test in mouse were used. RESULTS: The LD50 of HAN in male on 24 hour and 14 day was 186 mg/kg(185～187 mg/kg) and 183 mg/kg (182～184 mg/kg),respectively. No pathological change of the organs was found. There were significant findings in chromosome aberration and micronucleis rates in experimental groups compared with those of the negative control group(P<0.05). CONCLUSION: According to the standard of grading of acute toxicity,HAN belongs to the moderate class. The genetic damage of bone marrow cells can be induced by Hydroxylammonium Nitrate.

Key words: hydroxylammonium nitrate(HAN), acute toxicity, LD50, bone marrow cells, chromosomes, micronuclei

JIA Qing-jun, YANG Lu-jun, LIU Jin-yi, et al. Study on the Acute Toxicity and the Genetic Damage of Chromosome in Mice After Exposure to Hydroxylammonium Nitrate[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2004, 16(6): 359-361.

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Study on the Acute Toxicity and the Genetic Damage of Chromosome in Mice After Exposure to Hydroxylammonium Nitrate

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