DNA修复基因hOGG1多态与肺癌遗传易感性

doi:10.3969/j.issn.1004-616x.2005.02.010

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2005, Vol. 17 ›› Issue (2): 101-103.doi: 10.3969/j.issn.1004-616x.2005.02.010

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Genetic Polymorphism in hOGG1 and Susceptibility to Lung Cancer

WANG Wei;WU Yong-jun;WU Yi-ming

Department of Occupational Health and Health Toxicology, College of Public Health, Zhengzhou University，Henan Zhengzhou 450052, China

Received:2004-11-23 Revised:2004-12-21 Online:2005-03-30 Published:2005-03-30
Contact: WU Yi-ming

Abstract

Abstract: BACKGROUND ＆ AIM: To examine the association between Ser326Cys polymorphism in hOGG1 gene, which is involved in the repair of 8-hydroxyguanine in damaged DNA, and investigate the risk of lung cancer in Chinese. MATERIAL AND METHODS: Ser326Cys polymorphism in hOGG1 gene was determined by PCR-RFLP among 128 normal controls and 124 patients with lung cancer. The association between this genetic polymorphism and the risk of the cancer was examined by a multivariate analysis. RESULTS: The Cys/Cys genotype of hOGG1 was found in 19.4 ％ of patients with lung cancer and in 10.2 ％ of the controls (P<0.05). Homozygosity for the Cys/Cys genotype significantly increased the risk of developing cancer, with the odds ratio adjusted for age, sex and smoking being 2.12 (95 ％CI=1.03～4.39). CONCLUSION: Polymorphism of hOGG1 Ser326Cys may play a role in lung carcinogenesis.

Key words: hOGG1 gene, lung cancer, genetic polymorphism, susceptibility

WANG Wei, WU Yong-jun, WU Yi-ming. Genetic Polymorphism in hOGG1 and Susceptibility to Lung Cancer[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2005, 17(2): 101-103.

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Genetic Polymorphism in hOGG1 and Susceptibility to Lung Cancer

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