Carcinogenesis, Teratogenesis & Mutagenesis ›› 2005, Vol. 17 ›› Issue (2): 104-106.doi: 10.3969/j.issn.1004-616x.2005.02.011

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Inhibition of Tumor Cells by Ethanol Extract of Fomes Fomentarius

LIU Liang;ZHOU Shou-biao;ZHENG Wei-fa   

  1. Provincial Key Laboratory of Conservation and Exploitation of Biological Resources in Anhui,Institute of Life Science, Anhui NormalUniversity, Wuhu Anhui 241000, China
  • Received:2004-09-15 Revised:2004-11-17 Online:2005-03-30 Published:2005-03-30
  • Contact: ZHOU Shou-biao

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Abstract: BACKGROUND＆ AIM: To study the inhibition of tumor cells by ethanol extract of Fomes fomentarius(EEF) both in vivo and in vitro. MATERIAL AND METHODS： The influence of EEF on HeLa cells was assayed by MTT method. The effect of EEF on the apoptosis of S180 cells was analysed by FCM. The effect of EEF on the extending rates of mice carrying S180 tumor was investigated. MDA contents of several principle issues were observed, after the mice were dealed with EEF. RESULTS: EEF had obvious inhibitory activity to HeLa cells in vitro in a dose-dependent manner;could remarkably increase the apoptosis of S180 cells， the extending rates of mice carrying S180 tumor; MDA contents of liver, kindey were increased significantly,after the normal mice were treated by EEF. CONCLUSION: Ethanol extract of Fomes fomentarius has obvious inhibition on tumor cells.

Key words: Fomes fomentarius, anti-tumor, inhibitory effect