Carcinogenesis, Teratogenesis & Mutagenesis ›› 2005, Vol. 17 ›› Issue (4): 247-249.doi: 10.3969/j.issn.1004-616x.2005.04.015

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The Influence of Intraoperative Radiation Therapy on Immunity of Patients with Cervical Cancer in Stage

LIU Zi; WANG Guo-qing;LI Ming-zhong;LIU Juan-yue   

  1. Department of Tumor Radiotherapy,the First Affiliated ospital,Xi,an Jiaotong University,Xi,an 710061,Shaanxi,China
  • Received:2004-06-06 Revised:2004-10-10 Online:2005-07-30 Published:2005-07-30
  • Contact: LIU Zi

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Abstract: BACKGROUND ＆ AIM: To explore peripheral blood T-lymphocyte subsets and interleukin-2(IL-2) level in patients with cervical cancer in stage before and after intraoperation radiation therapy (IROT). MATERIAL AND METHODS: Before and after radiotherapy,the T-lymphocyte subsets and IL-2 were measured in 61 patients with cervical cancer in stage, including 28 patients with IROT and 31 ones with simple radiotherapy(SR),and contrasting to 20 normal controls by using flow cytometry and radio immune assay. RESULTS: After radiotherapy,the radio CD4,CD4/CD8 and IL-2 with IROT were significantly higher than those with SR. CONCLUSION: The influence of IROT on immunity of patients with cervical cancer in stage was lighter than that of SR.So,IROT contribute to recovery after radiotherapy.

Key words: cervical cancer, IROT, T-lymphocyte subsets, interleukin