Abstract: BACKGROUND ＆ AIM: To establish a model of mouse hepatoma H22 and to study the effects of Pingtiaoyin on the tumor. MATERIALS AND METHODS: The model of transplanted tumor was made by vaccination of hepatoma H22 in the right axilla.The model mice were divided into 4 groups:0.9％ NaCl,Pingtiaoyin,Pingtiaoyin＋5_Fu and 5_Fu.The diameter of transplanted tumor, inhibition rates,thymus and spleen indexes,the rates of life prolongation and the expression of VEGF in carcinoma and peri_carcinoma tissues were analyzed. RESULTS: The diameter of the tumor and the expression of VEGF in the carcinoma were reduced, thymus and spleen indexes,the inhibition rates and the life prolongation rates were increased after treatment with Pingtiaoyin. CONCLUSION: Pingtiaoyin could improve the thymus index,reduce the negative effect of 5_Fu on the immune function, and prolong the survival of the model mouse. Pingtiaoyin also could inhibit the growth of transplanted tumor in mouse through increasing the differentiation of carcinoma cells,reducing their proliferation and downregulating the expression of VEGF in carcinoma and pre_carcinoma tissues.

Key words: pingtiaoyin, mouse hepatoma H22, vascular endothelial growth factor (VEGF), anti_tumor