Carcinogenesis, Teratogenesis & Mutagenesis ›› 2009, Vol. 21 ›› Issue (4): 280-285.doi: 10.3969/j.issn.1004-616x.2009.04.008

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Polymorphisms of δ-Aminole- vulinic Acid Dehydratase; Vit D Receptor and Genetic Suscep- tibility of Lead Posioning in Han; Uygur and Kazak Children

CHEN Yan1; LIU Ji-wen1; ZHAO Jiang-xia1; CUI Jun2; LI Ling2; A Si-ya2; ZHU Yan3; TIAN Wei1   

  1. 1. College of Public Health; Xinjiang Medical University; Urumqi 830054; 2.Child Health Institute of Urumqi; Urumqi 830000; 3. Urumqi Children＇s Hospital; Urumqi 830002; China
  • Received:2008-11-12 Revised:2009-01-09 Online:2009-07-30 Published:2009-07-30
  • Contact: CHEN Yan

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Abstract: BACKGROUND AND AIM:To explore the polymorphisms of δ-aminolevulinic acid dehydratase(ALAD); vitamin D receptor(VDR) and genetic susceptibility of lead posioning in Han; Uygur and Kazak children. MATERIALS AND METHODS: The ALAD and VDR genotypings were determined by PCR-RFLP in 489 Han; 499 Uygur and 525 Kazak individuals from Urumqi city of Xinjiang province. RESULTS: The genotype frequencies of ALAD and VDR showed significant differences in Han; Uygur and Kazak subjects (P<0.01). According to VDR- BsmI、Taq I and Apa I haplotype analysis; haplotype Atb and AtB in Han were considerately decreased in lead poisoning group(P<0.05) while haplotype aTb and ATb significantly increased in lead poisoning group(P<0.01).However; such results were not found in Uygur and Kazak (P>0.05). CONCLUSION: A significant difference was seen in the frequency distribution of ALAD and VDR genotype among the different races. Haplotype Atb and AtB might be protective factors while haplotype ATb and aTb might be risk factors in Han.

Key words: δ-aminolevulinic acid dehydratase, vitamin D receptor, genetic polymorphism, haplotype, lead posioning

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