Carcinogenesis, Teratogenesis & Mutagenesis ›› 2010, Vol. 22 ›› Issue (3): 230-232.doi: 10.3969/j.issn.1004-616x.2010.03.017

Previous Articles     Next Articles

Combination of scopoletin and hesperetin from Ipomoea Stolonifera using uniform design experimentation

CHEN Yi-cun;CAI Cong-yi;JI Bin;GAO Fen-fei;ZHANG Yan-mei;HUANG Zhan-qin;BAI Xue-ting;SHI Gang-gang   

  1. Department of Pharmacology, Medical College, Shantou University, Shantou 515041, Guangdong, China
  • Received:2009-12-29 Revised:2010-03-01 Online:2010-05-30 Published:2010-05-30
  • Contact: SHI Gang-gang

PDF (PC)

1471

Abstract: OBJECTIVE:To analyze quantitatively the analgesic effect of scopoletin and hesperetin from Ipomoea Stolonifera in combination using the method of uniform design. METHODS: According to the uniform design method, 5 different doses at 5 different proportions were administered (intra-gastric) to observe the analgesic effect to mice by writhing test. The optimal doses and proportions in combination were obtained from experimental data, by mathematical analysis and professional knowledge. RESULTS: The combination of hesperetin at 194.5 mg/kg and scopoletin at 15.36 mg/kg was appropriate. CONCLUSION: The uniform design method could be effectively applied to analyze the multidrug effects under some limited conditions, but the results must be verified by further experiment.

Key words: Ipomoea Stolonifera, hesperetin, scopoletin, uniform design experimentation

CLC Number: