Carcinogenesis, Teratogenesis & Mutagenesis ›› 2007, Vol. 19 ›› Issue (5): 377-380.doi: 10.3969/j.issn.1004-616x.2007.05.009

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Differentiation of B16 Melanoma Induced by Proanthocyanidins from Lotus Seedpod

DUAN Yu_qing1,2,ZHANG Hai_hui1,WU Jia2,XIE Bi_jun2   

  1. (1.School of Biological and Environmental Engineering,Jiangsu University,Zhenjiang 212013;2.College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070,China)
  • Received:2006-10-20 Revised:2007-02-05 Online:2007-09-30 Published:2007-09-30
  • Contact: DUAN Yu_qing

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Abstract: BACKGROUND ＆ AIM: To investigate the differentiation of mice B16 melanoma induced by proanthocyanidins from lotus seedpod (LSPC)in vivo. MATERIALS AND METHODS: B16 melanoma_bearing mice were used to study the inhibitory effect of LSPC on B16 melanoma, the effect of LSPC on tyrosinase activity, and the ability of melanin formation, and the morphology change of B16 melonoma and the expression of S_100 protein. RESULTS: LSPC(60－120 mg/kg)could dose_dependently inhibit the growth of B16 melanoma,The effects in the group with dosage of 120 mg/kg was the most marked. The inhibition rate of B16 melonoma was 55.3％, while the activity of tyrosinase, the content of melanin increased 28.5％ and 23.8％,respectively. There were significant differences compared with control group(P<0.05). The expression of S_100 protein was down_regulated. CONCLUSION: LSPC could significantly inhibit the growth of mice B16 melanoma cells, and induce the differentiation of B16 melanoma cell in morphology and function.

Key words: lotus seedpod, proanthocyanidins, B16 melanoma, inhibitory effect, differentiation

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