氯化镉和顺铂联合对人肝癌细胞增殖的抑制作用

doi:10.3969/j.issn.1004-616x.2008.02.006

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2008, Vol. 20 ›› Issue (2): 100-102.doi: 10.3969/j.issn.1004-616x.2008.02.006

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Synergistical Suppressive Effect of Cadmium Chloride and Cisplatin on the Proliferation of Human Hepatoma Cell Line

LIU Xiao-mei, JIN Ming-hua, DU Hai-ying, LIU Ying, WANG Wen, SUN Zhi-wei

School of Public Health, Jilin University, Changchun 130021,China

Received:2007-05-09 Revised:2007-09-01 Online:2008-03-30 Published:2008-03-30
Contact: SUN Zhi-wei

Abstract

Abstract: BACKGROUND AND AIM: To investigate the synergistical suppressive effect of cadmium chloride and cisplation on the proliferation of human hepatoma cell line SMMC-7721. MATERIALS AND METHODS: Cytotoxicity of the drugs was measured by MTT assay. The coefficient of drug interaction(CDI) was used to analyze the synergistical suppressive effect of drug combination. RESULTS: 0.56、1.12、2.25 μg/ml cadmium chloride and 0.25、0.5、1.0 μg/ml cisplatins had inhibitory effects on the proliferation of SMMC-7721.The inhibition in cells treated with both agents was significant increased with treatment time. CONCLUSION: The combination of cadmium chloride and cisplatin could inhibit the proliferation of human hepatoma cell line SMMC-7721.

Key words: cadmium, cisplation(C-DDP), SMMC-7721, synergistical suppressive effect

LIU Xiao-mei, JIN Ming-hua, DU Hai-ying, LIU Ying, WANG Wen, SUN Zhi-wei. Synergistical Suppressive Effect of Cadmium Chloride and Cisplatin on the Proliferation of Human Hepatoma Cell Line[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2008, 20(2): 100-102.

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Synergistical Suppressive Effect of Cadmium Chloride and Cisplatin on the Proliferation of Human Hepatoma Cell Line

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