肺上皮样血管内皮瘤遗传学分析

doi:10.3969/j.issn.1004-616x.2009.03.007

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2009, Vol. 21 ›› Issue (3): 185-188.doi: 10.3969/j.issn.1004-616x.2009.03.007

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Cytogenetic Alterations in Lung Epithelioid Hemangioendothelioma

CAO Yan1，ZOU Shuang-mei1，FENG Ling2，LIU Yu2，WEN Peng1，HAN Nai-jun2，ZHANG Kai-tai2，LIN Dong-mei1

1. Department of Pathology, Cancer Institute＆Hospital of Chinese Academy of Medicine Science, Beijing 100021;2. Department of Etiology and Carcinogenesis, Cancer Institute＆Hospital of Chinese Academy of Medicine Science, Beijing 100021,China

Received:2009-02-18 Revised:2009-02-27 Online:2009-05-30 Published:2009-05-30

Abstract

Abstract: BACKGROUND AND AIM: To study the characteristics of cytogenetic alterations of lung epithelioid hemangioendothelioma. MATERIALS AND METHODS: Whole DNA was isolated from two formalin-fixed and paraffin-embedded tissues of lung epithelioid hemangioendothelioma. The DNA copy number changes were measured by array-comparative genomic hybridization(array-CGH). RESULTS: Two epithelioid hemangioendotheliomas showed many similar DNA copy number changes. Gains of small fragments(<10 Mb) were the most frequent change while deletions were infrequent.There were 150 and 556 genes involved with 77 sharing common changes. CONCLUSION: Amplifications of small fragments of DNA maybe the main cytogenetic alteration in lung epithelioid hemangioendothelioma, which may explain that epithelioid hemangioendothelioma is a low-grade malignant tumor.

Key words: epithelioid hemangioendothelioma, lung, array-CGH

CAO Yan, ZOU Shuang-mei, FENG Ling, LIU Yu, WEN Peng, HAN Nai-jun, ZHANG Kai-tai, LIN Dong-mei. Cytogenetic Alterations in Lung Epithelioid Hemangioendothelioma[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2009, 21(3): 185-188.

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Cytogenetic Alterations in Lung Epithelioid Hemangioendothelioma

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