朴菇多糖的急性毒性及遗传毒性试验研究

doi:10.3969/j.issn.1004-616x.2008.05.017

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2008, Vol. 20 ›› Issue (5): 406-408.doi: 10.3969/j.issn.1004-616x.2008.05.017

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Study on the Acute and Genetic Toxicities of Flammulina Velutipes Polysaccharide

CAO Li1, LIU Yan1, WEI Wei1, WU Song_ling2,

1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Beijing 100094; 2. Academy of State Grain Administration，Beijing 100037,China

Received:2008-02-25 Revised:2008-04-10 Online:2008-09-30 Published:2008-09-30

Abstract

Abstract: BACKGROUND AND AIM: To determine the acute oral toxicity and genetic toxicity of Flammulina velutipes polysaccharide. MATERIALS AND METHODS: Acute oral toxicity test, Ames test，micronucleus test of polychromatic erythrocytes in bone marrow， mice sperm shape abnormality test were used．RESULTS:The acute oral LD50 of Flammulina velutipes polysaccharide was greater than 10 g/kg in mice．The results of genetic toxicity tests were all negative. CONCLUSION: Genetic toxicity of Flammulina velutipes polysaccharide was not found, and it was classified as non_toxic agent．

Key words: Flammulina velutipes polysaccharide, acute oral toxicity, genetic toxicity

CAO Li, LIU Yan, WEI Wei, WU Song_ling, . Study on the Acute and Genetic Toxicities of Flammulina Velutipes Polysaccharide[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2008, 20(5): 406-408.

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Study on the Acute and Genetic Toxicities of Flammulina Velutipes Polysaccharide

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