[1] Bachrati CZ，Hickson ID. RecQ helicases：suppressors of tumorigenesis and premature aging[J]. Biochem J，2003， 374(Sup 3)：577-606.

[2] Soultanas P，Wigley DB. Unwinding the “Gordian knot” of helicase action[J]. Trends Biochem Sci，2001，26(1)：47-54.

[3] Bernstein DA，Keck JL. Domain mapping of Escherichia coli RecQ defines the roles of conserved N- and C-terminal regions in the RecQ family[J]. Nucleic Acids Res，2003，31(11)： 2778-2785.

[4] Lee JW，Kusumoto R，Doherty KM，et al. Modulation of Werner syndrome protein function by a single mutation in the conserved RecQ domain[J]. J Biol Chem，2005，280(47)： 39627-39636.

[5] Mohaghegh P，Hickson ID. DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders[J]. Hum Mol Genet，2001，10(7)：741-746.

[6] van Brabant AJ，Stan R，Ellis NA. DNA helicases，genomic instability，and human genetic disease[J]. Annu Rev Genomics Hum Genet，2000，1(4)：409-459.

[7] German J. Bloom's syndrome[J]. Dermatol Clin，1995，13(1)： 7-18.

[8] Hickson ID. RecQ helicases：caretakers of the genome[J]. Nat Rev Cancer，2003，3(3)：169-178.

[9] Meyerson M，Counter CM，Eaton EN，et al. hEST2，the putative human telomerase catalytic subunit gene，is up-regulated in tumor cells and during immortalization[J]. Cell，1997，90(4)：785-795.

[10] Liu JG，Yuan L，Brundell E，et al. Localization of the N-terminus of SCP1 to the central element of the synaptonemal complex and evidence for direct interactions between the N-termini of SCP1 molecules organized head-to-head[J]. Exp Cell Res，1996，226(1)：11-19.

[11] Gray MD，Shen JC，Kamath-Loeb AS，et al. The Werner syndrome protein is a DNA helicase[J]. Nat Genet，1997， 17(1)：100-103.

[12] Van Maldergem L，Siitonen HA，Jalkh N，et al. Revisiting the craniosynostosis-radial ray hypoplasia association：Baller-Gerold syndrome caused by mutations in the RECQL4 gene[J]. J Med Genet，2006，43(2)：148-152.

[13] Larizza L，Magnani I，Roversi G. Rothmund-Thomson syndrome and RECQL4 defect：splitting and lumping[J]. Cancer Lett，2006，232(1)：107-120.

[14] Bennett RJ，Keck JL. Structure and function of RecQ DNA helicases[J]. Crit Rev Biochem Mol Biol，2004，39(2)：79-97.

[15] 任  华. RecQ解旋酶分子特性的研究[D]. 上海：华东师范大学，2010.

[16] Ivankovic S，Dermic D. DNA end resection controls the balance between homologous and illegitimate recombination in Escherichia coli[J]. PLoS One，2012，7(6)：e39030.

[17] Monnat RJ. Human RECQ helicases：roles in DNA metabolism，mutagenesis and cancer biology[J]. Semin Cancer Biol，2010，20(5)：329-339.

[18] Tretiakova M，Turkyilmaz M，Grushko T，et al. Topoisomerase II alpha in Wilms' tumour：gene alterations and immunoexpression [J]. J Clin Pathol，2006，59(12)：1272-1277.

[19] Ramamoorthy M，Tadokoro T，Rybanska I，et al. RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression[J]. Nucleic Acids Res，2012，40 (4)：1621-1635.

[20] 丁秀艳. RecQ解旋酶的动力学机理研究[D]. 杨  凌：西北农林科技大学，2012.

[21] Hu Y，Raynard S，Sehorn MG，et al. RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments[J]. Genes Dev，2007，21(23)：3073-3084.

[22] Aygun O，Svejstrup J，Liu Y. A RECQ5-RNA polymerase II association identified by targeted proteomic analysis of human chromatin[J]. Proc Natl Acad Sci USA，2008，105(25)： 8580-8584.

[23] Aygun O，Xu X，Liu Y，et al. Direct inhibition of RNA polymerase II transcription by RECQL5[J]. J Biol Chem， 2009，284(35)：23197-23203.

[24] Chu WK，Hickson ID. RecQ helicases：multifunctional genome caretakers[J]. Nat Rev Cancer，2009，9(9)：644-654.

[25] Hu Y，Lu X，Barnes E，et al. RecQl5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers[J]. Mol Cell Biol，2005，25(9)：3431-3442.

[26] Wu L，Davies SL，Levitt NC，et al. Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51[J]. J Biol Chem，2001，276(22)：19375-19381.

[27] Johnson J，Bagley J，Skaznik-Wikiel M，et al. Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood[J]. Cell，2005，122(2)： 303-315.

[28] Serra H，Da IO，Degroote F，et al. Roles of XRCC2， RAD51B and RAD51D in RAD51-independent SSA recombination [J]. PLoS Genet，2013，9(11)：e1003971.

[29] Cheng L，Thomas A，Roth LM，et al. OCT4：a novel biomarker for dysgerminoma of the ovary[J]. Am J Surg Pathol，2004，28(10)：1341-1346.

[30] Courcelle J，Donaldson JR，Chow KH，et al. DNA damage-induced replication fork regression and processing in Escherichia coli[J]. Science，2003，299(5609)：1064-1067.

[31] Higgins NP，Kato K，Strauss B. A model for replication repair in mammalian cells[J]. J Mol Biol，1976，101(3)：417-425.

[32] Kanagaraj R，Saydam N，Garcia PL，et al. Human RecQ5 beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork[J]. Nucleic Acids Res，2006，34(18)：5217-5231.

[33] Zhi LQ，Ma W，Zhang H，et al. Association of RecQL5 gene polymorphisms and osteosarcoma in a Chinese Han population [J]. Tumor Biol，2014，35(4)：3255-3259.

[34] Qi Y，Zhou X. Haplotype analysis of RecQL5 gene and laryngeal cancer[J]. Tumor Biol，2014，35(3)：2669-2673.

[35] Mirabello L，Richards EG，Duong LM，et al. Telomere length and variation in telomere biology genes in individuals with osteosarcoma[J]. Int J Mol Epidemiol Genet，2011，2(1)：19-29.

[36] Zhang Y，Cai L，Wei RX，et al. Different expression of alternative lengthening of telomere (ALT)-associated proteins/ mRNAs in osteosarcoma cell lines[J]. Oncol Lett， 2011，2(6)： 1327-1332.

[37] Mirabello L，Yu K，Kraft P，et al. The association of telomere length and genetic variation in telomere biology genes[J]. Hum Mutat，2010，31(9)：1050-1058.

[38] Pellatt AJ，Wolff RK，Lundgreen A，et al. Genetic and lifestyle influence on telomere length and subsequent risk of colon cancer in a case control study[J]. Int J Mol Epidemiol Genet，2012，3(3)：184-194.

[39] Hu Y，Lu X，Luo G. Effect of RecQl5 deficiency on the intestinal tumor susceptibility of Apc(min) mice[J]. World J Gastroenterol，2010，16(12)：1482-1486.