| [1] Grivennikov S，Karin E，Terzic J，et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer[J]. Cancer Cell，2009，15 (2)：103-113. [2] Mantovani A. Inflammation and cancer：The macrophage connection[J]. Medicina，2007，67 (Sup 2)：32-34. [3] Noureen C，Pankaj C，Rushikes D. The role of bacteria in oral cancer [J]. Indian J Med Paediatr Oncol，2010，31 (4)：126-131. [4] Burmeister G，Tarcsay L，Sorg C. Generation and characterization of a monoclonal antibody (1C5) to human migration inhibitory factor (MIF)[J]. Immunobiology，1986，171 (4/5)：461-474. [5] Sch?fer BW，Heizmann CW. The S100 family of EF-hand calcium-binding proteins：functions and pathology[J]. Trends Biochem Sci， 1996，21 (4)：134-140. [6] Ghavami S，Kerkhoff C，Los M，et al. Mechanism of apoptosis induced by S100A8/A9 in colon cancer cell lines：the role of ROS and the effect of metal ions[J]. J Leukoc Biol，2004，76 (1)：169-175. [7] Vogl T，Gharibyan AL，Morozova-Roche LA. Pro-inflammatory S100A8 and S100A9 proteins：self-assembly into multifunctional native and amyloid complexes[J]. Int J Mol Sci，2012，13 (3)：2893-2917. [8] Kerkhoff C，Klempt M，Kaever V，et al. The two calcium-binding proteins， S100A8 and S100A9，are involved in the metabolism of arachidonic acid in human neutrophils[J]. J Biol Chem，1999，274 (2)：32672-32679. [9] Berthier S，Baillet A，Paclet MH，et al. How important are S100A8/ S100A9 calcium binding proteins for the activation of phagocyte NADPH oxidase，Nox2[J]. AIAAMC，2009，8 (4)：282-284. [10] Benedyk M，Sopalla C，Nacken W，et al. HaCaT keratinocytes overexpressing the S100 proteins S100A8 and S100A9 show increased NADPH oxidase and NF-kappaB activities[J]. J Invest Dermatol， 2007，127 (8)：2001-2011. [11] Voss A，Bode G，Sopalla C，et al. Expression of S100A8/A9 in HaCaT keratinocytes alters the rate of cell proliferation and differentiation[J]. EBS Lett，2011，585 (2)：440-446. [12] Wang J，Cai Y，Xu H，et al. Expression of MRPl4 gene is frequently down-regulated in Chinese human esophageal cancer[J]. Cell Res， 2004，14 (11)：46-53. [13] Alder H，Taccioli C，Chen H，et al. Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer[J]. Carcinogenesis，2012，33 (9)：1736-1744. [14] Taccioli C，Wan SG，Liu CG，et al. Zinc replenishment reverses overexpression of the proinflammatory mediator S100A8 and esophageal preneoplasia in the rat[J]. Gastroenterology，2009，136 (3)：953-966. [15] Taccioli C，Chen H，Jiang Y，et al. Dietary zinc deficiency fuels esophageal cancer development by inducing a distinct inflammatory signature[J]. Oncogene，2012，31 (42)：4550- 4558. [16] Wan SG，Taccioli C，Jiang YB，et al. Zinc deficiency activates S100A8 inflammation in the absence of COX-2 and promotes murine oral-esophageal tumor progression[J]. Int J Cancer，2011，129 (2)：331-345. [17] Hobbs JA，May R，Tanousis K，et al. Myeloid cell function in MRP-14 (S100A9) null mice[J]. Mol Cell Biol，2003，23 (7)：2564-2576. [18] Vogl T，Ludwig S，Goebeler M，et al. MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes[J]. Blood，2004，104 (13)：4260-4268. [19] Ehrchen JM，Sunderkotter C，Foell D，et al. The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection，autoimmunity，and cancer[J]. J Leukoc Biol，2009，86 (3)：557-566. [20] Sroussi HY，Berline J，Dazin P，et al. S100A8 triggers oxidation-sensitive repulsion of neutrophils[J]. J Dent Res，2006，85 (9)：829-833. [21] Corbin BD，Seeley EH，Raab A，et al. Metal chelation and inhibition of bacterial growth in tissue abscesses[J]. Science，2008，319 (5865)：962-965. [22] Clohessy PA，Golden BE. Calprotectin-mediated zinc chelation as a biostatic mechanism in host defence[J]. Scand J Immunol，1995，42 (5)：551-556. [23] Murthy A，Lerher R，Harwig S，et al. In vitro candidastatic properties of the human neutrophil calprotectin complex[J]. J Immunol，1993， 151：6291-6301. [24] Rector CL，Murphy RC. Determination of leukotriene A4 stabilization by S100A8/A9 proteins using mass spectrometry[J]. J Lipid Res， 2009，50 (10)：2064-2071. [25] Lackmann M，Cornish CJ，Simpson RJ，et al. Purification and structural analysis of a murine chemotactic cytokine (CP-10) with sequence homology to S100 proteins[J]. J Biol Chem，1992，267 (11)： 7499-7504. [26] Manitz MP，Horst B，Seeliger S，et al. Loss of S100A9 (MRP14) results in reduced interleukin-8-induced CD11b surface expression，a polarized microfilament system，and diminished responsiveness to chemoattractants in vitro[J]. Mol Cell Biol，2003，23 (3)：1034-1043. [27] Hiratsuka S，Watanabe A，Aburatani H，et al. Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis[J]. Nat Cell Biol，2006，8 (12)：1369-1375. [28] Huttunen HJ，Kuja-Panula J，Sorci G，et al. Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through receptor for advanced glycation end products (RAGE) activation[J]. J Biol Chem，2000，275 (51)：40096-40105. [29] Ghavami S，Eshragi M，Ande SR，et al. S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3[J]. Cell Res，2010， 20 (3)：314-331. [30] Johne B，Fagerhol MK，Lyberg T，et al. Functional and clinical aspects of the myelomonocyte protein calprotectin[J]. J Clin Pathol Mol Pathol，1997，50 (3)：113-123. [31] Rink L，Haase H. Zinc homeostasis and immunity[J]. Trends Immunol， 2007，28 (1)：1-4. [32] Halayko AJ，Ghavami S. S100A8/A9：a mediator of severe asthma pathogenesis and morbidity?[J]. Can J Physiol Pharmacol，2009，87 (10)：743-755. [33] Ghavami S，Rashedi I，Dattilo BM，et al. S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway[J]. J Leukoc Biol，2008，83 (6)：1484-1492. [34] Szlosarek P，Charles KA，Balkwill FR. Tumour necrosis factor-α as a tumour promoter[J]. Eurpean J of Cancer，2006，42 (6)：745-750. [35] Wang Y，Wang H，Piper MG，et al. sRAGE induces human monocyte survival and differentiation[J]. J Immunol，2010，185 (3)：1822-1835. [36] Sunahori K，Yamamura M，Yamana J，et al. The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis[J]. Arthrit Res & Ther，2006，8 (3)：69. [37] Gebhardt C，Riehl A，Durchdewald M，et al. RAGE signaling sustains inflammation and promotes tumor development[J]. J Exp Med，2008， 205 (2)：275-285. [38] Ichikawa M，Williams R，Wang L，et al. S100A8/A9 activate key genes and pathways in colon tumor progression[J]. Mol Cancer Res，2011，9 (2)：133-148. [39] Vallabhapurapu S，Karin M. Regulation and function of NF-κB transcription factors in the immune system[J]. Annu Rev Immunol， 2009，27 (1)：693-733. [40] Greten FR，Eckmann L，Greten TF，et al. IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer[J]. Cell，2004，118 (3)：285-296. |
