Carcinogenesis, Teratogenesis & Mutagenesis

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The effects of tributyltin on PP2A activity in mouse spleens, livers and brains

ZHANG Ya-li,SUN Yu-tao,WENG Deng-po,XU Li-hong*   

  1. (Department of Biochemistry and Genetics, School of Medicine, Zhejiang University, Hangzhou 310058, Zhejiang, China)
  • Received:2012-03-05 Revised:2012-05-23 Online:2013-05-30 Published:2013-05-30
  • Contact: XU Li-hong,Tel: 0571-88208265,E-mail: xulihong@ zju.edu.cn

Abstract:

OBJECTIVE: To investigate the effects of tributyltin(TBT) on the activity of protein phosphatase 2A(PP2A) in the mouse spleens,livers and brains. METHODS:Mice were orally dosed with 0,10,20 and 60 mg/kg of body weight TBT for 24 h and 96 h,and the activity of PP2A was assessed in the mouse spleens,livers,and brains. RESULTS:PP2A activity in the spleens was obviously inhibited in 20 and 60 mg/kg groups treated for 24 h and 96 h compared to the control group (P< 0.01). PP2A activity in the livers was significantly inhibited in the highest dose of TBT (60 mg/kg) for 96 h compared to the control group (P < 0.05). With regard to the PP2A activity in the brains,there were no statistical significance differences between the control and treatment groups (P>0.05). CONCLUSION:This study suggests a critical role of PP2A in the TBT immunologic and hepatic toxicity mechanisms.

Key words: tributyltin, PP2A, spleens, livers, brains